Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG2 | P78540 | 2/20 | 0.47 |
| ▸ | ARG1 | P05089 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 3/20 | 0.42 |
| ▸ | NOS1 | P29475 | 2/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | BHMT | Q93088 | 3/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.34 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.34 |
| ▸ | GRM8 | O00222 | 1/20 | 0.34 |
| ▸ | GRM6 | O15303 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GSR | P00390 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11564550 | 1.00 | ARG2 (0.47) | ARG2ARG1NOS2NOS1NOS3 | |
| SCHEMBL11568907 | 0.90 | ARG2 (0.52) | ARG2ARG1NOS2NOS1NOS3 | |
| SCHEMBL8081083 | 0.82 | ARG2 (0.46) | ARG2ARG1NOS2NOS1NOS3 | |
| SCHEMBL15795239 | 0.79 | ARG1 (0.50) | ARG2ARG1NOS2NOS1NOS3 | |
| SCHEMBL15795237 | 0.79 | ARG1 (0.50) | ARG2ARG1NOS2NOS1NOS3 | |
| SCHEMBL36935 | 0.78 | ARG1 (0.61) | ARG2ARG1NOS2NOS1NOS3 | |
| SCHEMBL36934 | 0.78 | ARG1 (0.61) | ARG2ARG1NOS2NOS1NOS3 | |
| SCHEMBL29378137 | 0.78 | ARG1 (0.61) | ARG2ARG1NOS2NOS1NOS3 | |
| SCHEMBL36933 | 0.78 | ARG1 (0.61) | ARG2ARG1NOS2NOS1NOS3 | |
| SCHEMBL29393779 | 0.78 | ARG1 (0.61) | ARG2ARG1NOS2NOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3334498-B1 | METHODS OF TREATING VOLUME DEPLETION AND KIDNEY INJURY | UNIV COLUMBIA (US) | 2023-06-07 | — | — | EP | disclosed |
| US-11119104-B2 | Methods of treating volume depletion and kidney injury | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-09-14 | — | — | US | disclosed |
| EP-3334498-A1 | METHODS OF TREATING VOLUME DEPLETION AND KIDNEY INJURY | The Trustees of Columbia University in the City of New York (US) | 2018-06-20 | — | — | EP | disclosed |
| EP-2593472-B1 | ANCESTRAL PROTEINS | UNIV COLUMBIA (US) | 2018-05-16 | — | — | EP | disclosed |
| US-9880088-B2 | Force-clamp spectrometer with functionalized cantilever tip | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-01-30 | — | — | US | disclosed |
| US-20180016562-A1 | ANCESTRAL PROTEINS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2018-01-18 | — | — | US | disclosed |
| US-9682123-B2 | Methods of treating metabolic disease | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-06-20 | — | — | US | disclosed |
| WO-2017027858-A1 | METHODS OF TREATING VOLUME DEPLETION AND KIDNEY INJURY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-02-16 | — | — | WO | disclosed |
| US-20150190466-A1 | METHODS OF TREATING METABOLIC DISEASE | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2015-07-09 | — | — | US | disclosed |
| US-20130252307-A1 | ANCESTRAL PROTEINS | GEORGIA TECH RESEARCH CORPORATION (US) | 2013-09-26 | — | — | US | disclosed |
| US-20060269918-A1 | Compositions, splice variants and methods relating to colon specific genes and proteins | DIADEXUS, INC. | 2006-11-30 | — | — | US | disclosed |
| US-20060269917-A1 | Compositions, splice variants and methods relating to colon specific gene and proteins | MACINA ROBERTO A | 2006-11-30 | — | — | US | disclosed |
| US-20060199180-A1 | Compositions and methods relating to ovarian specific genes and proteins | DIADEXUS, INC. | 2006-09-07 | — | — | US | disclosed |
| US-20060051759-A1 | Compositions and methods relating to breast specific genes and proteins | SALCEDA SUSANA | 2006-03-09 | — | — | US | disclosed |
| US-20050214781-A1 | Compositions, splice variants and methods relating to ovarian specific nucleic acids and proteins | DIADEXUS INC. | 2005-09-29 | — | — | US | disclosed |
| US-20050208062-A1 | Compositions and methods relating to hepatic specific genes and proteins | SUN YONGMING | 2005-09-22 | — | — | US | disclosed |
| US-20050130154-A1 | Nucleic acids encoding polypeptides present in normal and neoplastic endometrial cells for use in diagnosis and treatment of endometrial cancer, identifying endometrial tissue; vaccines against endometrial cancer | SUN YONGMING (US) | 2005-06-16 | — | — | US | disclosed |
| US-20050123551-A1 | Compositions and methods relating to endometrial specific genes and proteins | SUN YONGMING (US) | 2005-06-09 | — | — | US | disclosed |
| US-20050079515-A1 | Compositions, splice variants and methods relating to breast specific nucleic acids and proteins | DIADEXUS, INC. | 2005-04-14 | — | — | US | disclosed |
| US-20050048534-A1 | Compositions, splice variants and methods relating to colon specific genes and proteins | MACINA ROBERTO A (US) | 2005-03-03 | — | — | US | disclosed |