Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.30 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3588863 | 0.95 | ENPP2 (0.34) | ENPP2KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL13031176 | 0.83 | HTT (0.38) | KDM4EALDH1A1GAASMN1; SMN2HDAC1 | |
| Trifluoroacetic Acid SCHEMBL3582020 | 0.79 | GAA (0.33) | KDM4EGAASMN1; SMN2HDAC1HDAC7 | |
| SCHEMBL31105945 | 0.77 | KDM4E (0.36) | ENPP2KDM4EALDH1A1KMT2APLA2G7 | |
| SCHEMBL3588460 | 0.73 | SMN1; SMN2 (0.38) | KDM4EALDH1A1GAASMN1; SMN2KMT2A | |
| SCHEMBL17151558 | 0.73 | ALDH1A1 (0.40) | KDM4EALDH1A1GAASMN1; SMN2SHMT2 | |
| SCHEMBL22057158 | 0.72 | KDM4E (0.38) | ENPP2KDM4EALDH1A1KMT2AMTNR1A | |
| SCHEMBL26454238 | 0.71 | ALDH1A1 (0.39) | ENPP2KDM4EALDH1A1KMT2APLA2G7 | |
| SCHEMBL25925090 | 0.71 | ALDH1A1 (0.36) | ENPP2KDM4EALDH1A1GAAKMT2A | |
| SCHEMBL18310021 | 0.71 | KDM4E (0.37) | ENPP2KDM4EALDH1A1KMT2AFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100286191-A1 | 2-Arylthiazole Derivatives as CXCR3 Receptor Modulators | MERCK SHARP & DOHME CORP. | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286191-A1 | 2-Arylthiazole Derivatives as CXCR3 Receptor Modulators | CXCR3, CXCR1, CXCR2 | ENPP2 262/4885KDM4E 3447/4885ALDH1A1 971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.