Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 3/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6559487 | 0.98 | HTR2B (0.45) | HTR2BSIGMAR1HTR1AMAPTALDH1A1 | |
| SCHEMBL3578838 | 0.88 | MAPT (0.47) | HTR2BSIGMAR1HTR1AMAPTALDH1A1 | |
| SCHEMBL25659983 | 0.83 | MAPT (0.45) | HTR2BSIGMAR1HTR1AMAPTALDH1A1 | |
| SCHEMBL7470852 | 0.82 | KCNE1 (0.47) | HTR2BSIGMAR1HTR1AMAPTALDH1A1 | |
| SCHEMBL21949769 | 0.82 | MAPT (0.44) | HTR2BSIGMAR1HTR1AMAPTALDH1A1 | |
| SCHEMBL618191 | 0.81 | HTR2B (0.40) | HTR2BSIGMAR1HTR1AMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL6558668 | 0.81 | CA2 (0.37) | MAPTALDH1A1HTTTAAR1SMN1; SMN2 | |
| SCHEMBL11246000 | 0.80 | HTR2B (0.40) | HTR2BSIGMAR1HTR1AMAPTHTT | |
| SCHEMBL7479500 | 0.80 | HTR2C (0.42) | HTR2BSIGMAR1HTR1AHTTSMN1; SMN2 | |
| SCHEMBL6601951 | 0.79 | MAOB (0.53) | HTR2BSIGMAR1MAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174492-A1 | SUBSTITUTED CONDENSED AZINES AS ANTHELMINTIC COMPOUNDS | ELANCO ANIMAL HEALTH GMBH (DE) | 2023-06-08 | — | — | US | disclosed |
| US-20230141809-A1 | QUINOLINE DERIVATIVES | ELANCO ANIMAL HEALTH GMBH (DE) | 2023-05-11 | — | — | US | disclosed |
| US-11572357-B2 | Quinoline derivatives | BAYER ANIMAL HEALTH GMBH (DE) | 2023-02-07 | — | — | US | disclosed |
| US-20210139468-A1 | NEW QUINOLINE DERIVATIVES | ELANCO ANIMAL HEALTH GMBH (DE) | 2021-05-13 | — | — | US | disclosed |
| US-20210115026-A1 | NEW ANTHELMINTIC QUINOLINE-3-CARBOXAMIDE DERIVATIVES | ELANCO ANIMAL HEALTH GMBH (DE) | 2021-04-22 | — | — | US | disclosed |
| US-7662811-B2 | N-(((5R)-5-((1-methylethyl)amino)-5,6,7,8-tetrahydro-2-naphthalenyl)methyl)-2-((2R)-1-((4-methylphenyl)sulfonyl)-3-oxo-1,2,3,4-tetrahydro-2-pyrazinyl)acetamide; for treatment of pain and diseases, such as inflammation mediated diseases | AMGEN INC. (US) | 2010-02-16 | — | — | US | disclosed |
| US-20060025400-A1 | 1,2,3,4-Tetrahydropyrazin-2-yl acetamides and methods of use | AMGEN INC. | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139468-A1 | NEW QUINOLINE DERIVATIVES | RECQL, QTRT2, NQO2 | HTR2B 1205/4885SIGMAR1 702/4885HTR1A 967/4885 |
| US-20060025400-A1 | 1,2,3,4-Tetrahydropyrazin-2-yl acetamides and methods of use | AADAC, PTGES2, LTC4S | HTR2B 1712/4885SIGMAR1 832/4885HTR1A 2353/4885 |
| US-20230141809-A1 | QUINOLINE DERIVATIVES | RECQL, NQO2, QTRT2 | HTR2B 1050/4885SIGMAR1 955/4885HTR1A 918/4885 |
| US-20210115026-A1 | NEW ANTHELMINTIC QUINOLINE-3-CARBOXAMIDE DERIVATIVES | HRH4, HRH2, HRH1 | HTR2B 1192/4885SIGMAR1 1066/4885HTR1A 844/4885 |
| US-11572357-B2 | Quinoline derivatives | RECQL, NQO2, QTRT2 | HTR2B 1087/4885SIGMAR1 965/4885HTR1A 950/4885 |
| US-20230174492-A1 | SUBSTITUTED CONDENSED AZINES AS ANTHELMINTIC COMPOUNDS | H1-5, H1-10, H1-0 | HTR2B 1546/4885SIGMAR1 3787/4885HTR1A 329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.