Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 7/20 | 0.52 |
| ▸ | PLK4 | O00444 | 3/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 6/20 | 0.43 |
| ▸ | CCND1 | P24385 | 5/20 | 0.43 |
| ▸ | CCND3 | P30281 | 4/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.43 |
| ▸ | CCND2 | P30279 | 3/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.43 |
| ▸ | CCNK | O75909 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 3/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580939 | 0.91 | CDK4 (0.53) | JAK2CDK4CCND1CCND3CDK2 | |
| SCHEMBL3587627 | 0.87 | CDK4 (0.35) | STAT6JAK2CDK4CCND1CCND3 | |
| SCHEMBL3575913 | 0.83 | NPC1 (0.41) | JAK2CDK4CCND1CCND3CDK2 | |
| SCHEMBL3583463 | 0.82 | CDK4 (0.52) | STAT6IGF1RJAK2CDK4CCND1 | |
| SCHEMBL3586266 | 0.81 | AURKA (0.42) | CDK4CCND1CCND3CDK2CCND2 | |
| SCHEMBL1355881 | 0.78 | STAT6 (0.57) | STAT6PLK4IGF1RJAK2CDK4 | |
| SCHEMBL3585927 | 0.75 | STAT6 (0.53) | STAT6PLK4IGF1RJAK2CDK4 | |
| SCHEMBL1355600 | 0.73 | SYK (0.54) | STAT6PLK4IGF1RCDK4CCND1 | |
| SCHEMBL3579094 | 0.73 | CDK4 (0.50) | JAK2CDK4CCND1CCND3CDK2 | |
| SCHEMBL1356073 | 0.72 | STAT6 (0.50) | STAT6PLK4IGF1RJAK2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | claimed |
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | CDK1, BUB1, BUB1B | STAT6 2276/4885PLK4 13/4885IGF1R 3119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.