Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912570 | 0.87 | SMN1; SMN2 (0.82) | SMN1; SMN2KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL3034646 | 0.85 | SMN1; SMN2 (0.83) | SMN1; SMN2KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL95008 | 0.84 | SMN1; SMN2 (0.73) | SMN1; SMN2KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL14531874 | 0.84 | SMN1; SMN2 (0.73) | SMN1; SMN2KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL13947384 | 0.84 | SMN1; SMN2 (0.73) | SMN1; SMN2KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL28649262 | 0.82 | SMN1; SMN2 (0.69) | SMN1; SMN2KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL1568246 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL3583496 | 0.81 | NPC1 (0.51) | SMN1; SMN2KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL27917765 | 0.79 | ALDH1A1 (0.51) | SMN1; SMN2KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL28654120 | 0.79 | SMN1; SMN2 (0.68) | SMN1; SMN2KMT2ANPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9000022-B2 | Imidazole based LXR modulators | EXELIXIS PATENT COMPANY LLC (US) | 2015-04-07 | — | — | US | disclosed |
| US-9000022-B2 | Imidazole based LXR modulators | EXELIXIS PATENT COMPANY LLC (US) | 2015-04-07 | — | — | US | disclosed |
| US-9000022-B2 | Imidazole based LXR modulators | EXELIXIS PATENT COMPANY LLC (US) | 2015-04-07 | — | — | US | disclosed |
| EP-1910308-B1 | IMIDAZOLE BASED LXR MODULATORS | EXELIXIS PATENT CO LLC (US) | 2014-09-03 | — | — | EP | disclosed |
| EP-1910308-B1 | IMIDAZOLE BASED LXR MODULATORS | EXELIXIS PATENT CO LLC (US) | 2014-09-03 | — | — | EP | disclosed |
| US-20140038964-A1 | IMIDAZOLE BASED LXR MODULATORS | EXELIXIS PATENT COMPANY LLC (US) | 2014-02-06 | — | — | US | disclosed |
| US-20140038964-A1 | IMIDAZOLE BASED LXR MODULATORS | EXELIXIS PATENT COMPANY LLC (US) | 2014-02-06 | — | — | US | disclosed |
| US-20140038964-A1 | IMIDAZOLE BASED LXR MODULATORS | EXELIXIS PATENT COMPANY LLC (US) | 2014-02-06 | — | — | US | disclosed |
| US-8569352-B2 | Imidazole based LXR modulators | EXELIXIS PATENT COMPANY LLC (US) | 2013-10-29 | — | — | US | disclosed |
| US-8569352-B2 | Imidazole based LXR modulators | EXELIXIS PATENT COMPANY LLC (US) | 2013-10-29 | — | — | US | disclosed |
| CN-101248049-A | Imidazole based LXR modulators | EXELIXIS INC (US) | 2008-08-20 | — | — | CN | disclosed |
| EP-1910308-A1 | IMIDAZOLE BASED LXR MODULATORS | Exelixis, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1322608-B1 | DELTA1-PYRROLINES USED AS PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2007-05-02 | — | — | EP | disclosed |
| EP-1322608-B1 | DELTA1-PYRROLINES USED AS PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2007002563-A1 | IMIDAZOLE BASED LXR MODULATORS | EXELIXIS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |
| WO-2007002563-A1 | IMIDAZOLE BASED LXR MODULATORS | EXELIXIS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |
| US-6995185-B2 | Δ1-pyrrolines used as pesticides | BAYER CROPSCIENCE AG (DE) | 2006-02-07 | — | — | US | disclosed |
| US-20040068122-A1 | Delta1-pyrrolines used as pesticides | BAYER CROPSCIENCE AG (DE) | 2004-04-08 | — | — | US | disclosed |
| EP-1322608-A1 | DELTA1-PYRROLINES USED AS PESTICIDES | Bayer CropScience AG (DE) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024646-A1 | DELTA1-PYRROLINES USED AS PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140038964-A1 | IMIDAZOLE BASED LXR MODULATORS | NR1H2, NR1H3, NR1H4 | SMN1; SMN2 4301/4885KMT2A 988/4885NPC1 39/4885 |
| US-20040068122-A1 | Delta1-pyrrolines used as pesticides | DDT, ADRA1D, OPRD1 | SMN1; SMN2 1679/4885KMT2A 3327/4885NPC1 4206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.