Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | FASN | P49327 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18584332 | 0.89 | PTGES (0.49) | HSD11B1ALDH1A1KMT2AKDM4EGAA | |
| SCHEMBL356250 | 0.85 | KDM5A (0.49) | ALDH1A1HPGDLMNAGFERKMT2A | |
| SCHEMBL5559581 | 0.80 | HSD11B1 (0.39) | HSD11B1ALDH1A1HPGDLMNAGFER | |
| Hydrochloric Acid SCHEMBL13280195 | 0.76 | KCNH2 (0.39) | HSD11B1ALDH1A1HPGDLMNAGFER | |
| SCHEMBL13280383 | 0.75 | ALDH1A1 (0.41) | ALDH1A1HPGDKDM4EHSD17B10GAA | |
| SCHEMBL2870927 | 0.74 | KDM5A (0.47) | ALDH1A1HPGDKDM4EGAAFASN | |
| SCHEMBL359185 | 0.74 | PDE9A (0.48) | ALDH1A1HPGDKDM4EHSD17B10GAA | |
| SCHEMBL13280613 | 0.74 | TDP1 (0.34) | HSD11B1ALDH1A1HPGDLMNAGFER | |
| SCHEMBL13280424 | 0.74 | MCHR1 (0.38) | HSD11B1ALDH1A1MAPTHTTPTGES | |
| SCHEMBL18584520 | 0.73 | FEN1 (0.51) | ALDH1A1KMT2AKDM4EMAPTPTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2696682-A2 | MIF INHIBITORS AND THEIR USES | Innovimmune Biotherapeutics, Inc. (US) | 2014-02-19 | — | — | EP | disclosed |
| EP-2592933-A1 | MIF INHIBITORS AND THEIR USES | Gaweco, Anderson (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012142498-A2 | MIF INHIBITORS AND THEIR USES | INNOVIMMUNE BIOTHERAPEUTICS, INC. (US) | 2012-10-18 | — | — | WO | disclosed |
| WO-2012009649-A1 | MIF INHIBITORS AND THEIR USES | GAWECO ANDERSON (US) | 2012-01-19 | — | — | WO | disclosed |