Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3599830 | 0.86 | HDAC1 (0.46) | SMN1; SMN2KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL3596585 | 0.79 | NPC1 (0.46) | SMN1; SMN2KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL3854495 | 0.79 | LMNA (0.60) | SMN1; SMN2KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL3595117 | 0.73 | RAB9A (0.40) | SMN1; SMN2KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL3596581 | 0.73 | ALDH1A1 (0.44) | SMN1; SMN2KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL2150013 | 0.73 | ALDH1A1 (0.44) | SMN1; SMN2KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL3849125 | 0.71 | RAB9A (0.56) | SMN1; SMN2KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL2575677 | 0.69 | CES2 (0.55) | SMN1; SMN2KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL2575679 | 0.69 | CES2 (0.55) | SMN1; SMN2KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL18554814 | 0.69 | ALDH1A1 (0.53) | SMN1; SMN2KMT2ANPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709491-B2 | Substituted quinazolines as antiviral agents, especially against cytomegaloviruses | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-05-04 | — | — | US | disclosed |
| US-20060235032-A1 | Substituted quinazolines as antiviral agents, especially against cytomegaloviruses | AIC246 AG & CO. KG (DE) | 2006-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235032-A1 | Substituted quinazolines as antiviral agents, especially against cytomegaloviruses | TPMT, EIF2AK2, IRF3 | SMN1; SMN2 3744/4885KMT2A 2130/4885NPC1 2269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.