Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 5/20 | 0.33 |
| ▸ | SLC6A4 known ✓ | P31645 | 5/20 | 0.33 |
| ▸ | HTR1A known ✓ | P08908 | 4/20 | 0.33 |
| ▸ | HTR3A known ✓ | P46098 | 4/20 | 0.33 |
| ▸ | SLC6A3 known ✓ | Q01959 | 4/20 | 0.33 |
| ▸ | HTR2C | P28335 | 6/20 | 0.46 |
| ▸ | HTR2B | P41595 | 6/20 | 0.46 |
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3614414 | 0.81 | HTR6 (0.37) | HTR2CHTR2BHTR2ATAAR1SLC6A2 | |
| Hydrochloric Acid SCHEMBL3608535 | 0.80 | HTR2A (0.40) | HTR2CHTR2BHTR2ATAAR1HTR1A | |
| Hydrochloric Acid SCHEMBL3604596 | 0.79 | ADRB1 (0.45) | HTR2CHTR2BHTR2ATAAR1CYP1A2 | |
| Hydrochloric Acid SCHEMBL3610733 | 0.78 | ADRB1 (0.48) | HTR2CHTR2BHTR2AHTR1AHTR3A | |
| Hydrochloric Acid SCHEMBL3608048 | 0.75 | HTR2C (0.38) | HTR2CHTR2BHTR2ATAAR1 | |
| Hydrochloric Acid SCHEMBL3609734 | 0.75 | TAAR1 (0.42) | HTR2CHTR2BHTR2ATAAR1SLC6A2 | |
| Bromide SCHEMBL3602839 | 0.74 | MAPT (0.42) | HTR1A | |
| Hydrochloric Acid SCHEMBL3609465 | 0.74 | ADRB1 (0.47) | HTR2CHTR2BHTR2AHTR1AHTR3A | |
| Hydrochloric Acid SCHEMBL3611639 | 0.74 | ALOX5 (0.44) | HTR2CHTR2BHTR2A | |
| Bromide SCHEMBL3596621 | 0.73 | HTR2C (0.46) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004249-A1 | Bicyclic heterocyclic compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-01-07 | — | — | US | disclosed |
| EP-2039695-A1 | BICYCLIC HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2009-03-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004249-A1 | Bicyclic heterocyclic compound and use thereof | HTR2C, HTR5A, HTR2A | SLC6A2 78/4885SLC6A4 21/4885HTR1A 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.