Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.76 |
| ▸ | NLRP3 | Q96P20 | 8/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | SCN1A | P35498 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MC4R | P32245 | 1/20 | 0.49 |
| ▸ | SCN4A | P35499 | 1/20 | 0.49 |
| ▸ | MC3R | P41968 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1026418 | 0.91 | MAPK1 (0.72) | MAPK1NLRP3HPGDLMNAALDH1A1 | |
| SCHEMBL9356536 | 0.90 | MAPK1 (0.63) | MAPK1NLRP3HPGDLMNAALDH1A1 | |
| SCHEMBL28969409 | 0.88 | MAPK1 (0.69) | MAPK1NLRP3HPGDLMNAALDH1A1 | |
| SCHEMBL9359788 | 0.87 | NLRP3 (0.78) | MAPK1NLRP3HPGDLMNAALDH1A1 | |
| SCHEMBL1954916 | 0.82 | LMNA (0.74) | MAPK1NLRP3HPGDLMNAALDH1A1 | |
| SCHEMBL1024875 | 0.82 | MAPK1 (0.61) | MAPK1NLRP3HPGDLMNAALDH1A1 | |
| SCHEMBL10779722 | 0.81 | MAPK1 (0.57) | MAPK1NLRP3HPGDLMNAALDH1A1 | |
| SCHEMBL17856292 | 0.81 | NPC1 (0.65) | MAPK1NLRP3HPGDLMNAALDH1A1 | |
| SCHEMBL1023754 | 0.81 | MAPK1 (0.60) | MAPK1NLRP3HPGDLMNAALDH1A1 | |
| SCHEMBL3106554 | 0.80 | MAPK1 (0.52) | MAPK1NLRP3HPGDLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5079383-A | With A Methylating Agent Using A Zinc Halide Catalyst | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-01-07 | — | — | US | claimed |
| US-20100063044-A1 | SUBSTITUTED ANILINE DERIVATIVES | H. LUNDBECK A/S (DK) | 2010-03-11 | — | — | US | disclosed |
| US-7601870-B2 | Such as Hexanoic acid (4-bromo-2,6-dimethyl-phenyl)-amide; potassium channel modulators; epilepsy | H. LUNDBECK A/S (DK) | 2009-10-13 | — | — | US | disclosed |
| EP-1791809-A1 | SUBSTITUTED ANILINE DERIVATIVES | H. LUNDBECK A/S (DK) | 2007-06-06 | — | — | EP | disclosed |
| US-20060155121-A1 | Substituted aniline derivatives | H. LUNDBECK A/S (DK) | 2006-07-13 | — | — | US | disclosed |
| WO-2006029623-A1 | SUBSTITUTED ANILINE DERIVATIVES | H. LUNDBECK A/S (DK) | 2006-03-23 | — | — | WO | disclosed |
| EP-0410684-B1 | Method of condensing N-phenylcarbamates | ENICHEM SINTESI (IT) | 1994-11-30 | — | — | EP | disclosed |
| US-5079383-A | With A Methylating Agent Using A Zinc Halide Catalyst | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-01-07 | — | — | US | disclosed |
| EP-0410684-A2 | Method of condensing N-phenylcarbamates | ENICHEM SYNTHESIS S.p.A. (IT) | 1991-01-30 | — | — | EP | disclosed |
| EP-0110732-B1 | PROCESS FOR PRODUCING DIPHENYLMETHANE DICARBAMATES | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1987-03-11 | — | — | EP | disclosed |
| EP-0123412-B1 | METHOD FOR MANUFACTURE OF DIPHENYLMETHANE DIISOCYANATES | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1986-07-09 | — | — | EP | disclosed |
| US-4552974-A | Process for producing diphenylmethane dicarbamates | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1985-11-12 | — | — | US | disclosed |
| US-4547322-A | Method for manufacture of diphenylmethane diisocyanates | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1985-10-15 | — | — | US | disclosed |
| EP-0123412-A1 | Method for manufacture of diphenylmethane diisocyanates | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1984-10-31 | — | — | EP | disclosed |
| EP-0110732-A2 | Process for producing diphenylmethane dicarbamates | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1984-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063044-A1 | SUBSTITUTED ANILINE DERIVATIVES | NDUFS3, NAT1, PRMT3 | MAPK1 2784/4885NLRP3 3233/4885HPGD 3916/4885 |
| US-20060155121-A1 | Substituted aniline derivatives | UGT2B7, NAT1, CYP1A2 | MAPK1 1940/4885NLRP3 4464/4885HPGD 2100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.