Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | AMPD1 | P23109 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11609568 | 0.68 | SMN1; SMN2 (0.41) | SMN1; SMN2TSHRKAT2BHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL10553606 | 0.68 | — | — | |
| SCHEMBL1174031 | 0.68 | TSHR (0.48) | SMN1; SMN2TSHRKAT2BBRD4KDM4E | |
| SCHEMBL3593370 | 0.65 | CYP19A1 (0.33) | — | |
| SCHEMBL15781674 | 0.64 | SMN1; SMN2 (0.50) | SMN1; SMN2TSHRKAT2BBRD4HSD17B10 | |
| SCHEMBL20814097 | 0.62 | SMN1; SMN2 (0.49) | SMN1; SMN2HSD17B10ALDH1A1LMNA | |
| SCHEMBL8939849 | 0.61 | SMN1; SMN2 (0.44) | SMN1; SMN2TSHRKAT2BHSD17B10KDM4E | |
| SCHEMBL3601322 | 0.61 | BRD4 (0.37) | BRD4 | |
| SCHEMBL11152896 | 0.61 | SMN1; SMN2 (0.41) | SMN1; SMN2TSHRKAT2BBRD4KDM4E | |
| SCHEMBL1174392 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728028-B2 | Substituted imidazoline compounds | GRUENENTHAL GMBH (DE) | 2010-06-01 | — | — | US | disclosed |
| US-20090048323-A1 | SUBSTITUTED IMIDAZOLINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048323-A1 | SUBSTITUTED IMIDAZOLINE COMPOUNDS | ITCH, OPRK1, ALDH1A1 | SMN1; SMN2 965/4885TSHR 2305/4885KAT2B 984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.