Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RRM1 | P23921 | 2/20 | 0.64 |
| ▸ | RRM2B | Q7LG56 | 2/20 | 0.64 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.64 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.64 |
| ▸ | ATP4A | P20648 | 3/20 | 0.59 |
| ▸ | ATP4B | P51164 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 11/20 | 0.58 |
| ▸ | MEN1 | O00255 | 10/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.58 |
| ▸ | GAA | P10253 | 9/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.58 |
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | ALPL | P05186 | 2/20 | 0.55 |
| ▸ | ALPI | P09923 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3594785 | 0.84 | MAPT (0.65) | ATP4AATP4BMEN1KMT2AGAA | |
| SCHEMBL30660072 | 0.82 | RAB9A (0.67) | MEN1KMT2AGAAKDM4EMAPT | |
| SCHEMBL3602570 | 0.82 | ABL1 (0.67) | ATP4AATP4BALDH1A1SMN1; SMN2HTT | |
| SCHEMBL3608900 | 0.82 | RAB9A (0.67) | MEN1KMT2AGAAKDM4EMAPT | |
| SCHEMBL3601590 | 0.81 | MEN1 (0.52) | RRM1RRM2BHSPD1HSPE1POLB | |
| SCHEMBL3605903 | 0.81 | RRM1 (0.53) | RRM1RRM2BHSPD1HSPE1POLB | |
| SCHEMBL3604799 | 0.81 | ALOX5 (0.61) | HSPD1HSPE1ATP4AATP4BMEN1 | |
| SCHEMBL10036568 | 0.80 | RRM1 (0.71) | RRM1RRM2BHSPD1HSPE1POLB | |
| SCHEMBL3607108 | 0.80 | ABL1 (0.49) | HSPD1HSPE1POLBMEN1KMT2A | |
| SCHEMBL3599324 | 0.80 | ABL1 (0.57) | HSPD1HSPE1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298340-A1 | Thiazol-Guanidine Derivatives Useful As A (Beta)-Related Pathologies | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | claimed |
| US-20100298340-A1 | Thiazol-Guanidine Derivatives Useful As A (Beta)-Related Pathologies | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | disclosed |
| EP-2010508-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120096-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298340-A1 | Thiazol-Guanidine Derivatives Useful As A (Beta)-Related Pathologies | GRN, MAPT, GUCY1B1 | RRM1 4337/4885RRM2B 3029/4885HSPD1 524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.