Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MMP1 | P03956 | 4/20 | 0.44 |
| ▸ | MMP2 | P08253 | 3/20 | 0.44 |
| ▸ | MMP9 | P14780 | 3/20 | 0.44 |
| ▸ | MMP12 | P39900 | 3/20 | 0.44 |
| ▸ | MMP14 | P50281 | 3/20 | 0.44 |
| ▸ | MMP15 | P51511 | 3/20 | 0.44 |
| ▸ | MMP16 | P51512 | 3/20 | 0.44 |
| ▸ | MMP26 | Q9NRE1 | 3/20 | 0.44 |
| ▸ | MMP7 | P09237 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3608697 | 0.83 | MMP8 (0.46) | TP53MAPTMMP1MMP2MMP9 | |
| SCHEMBL3603136 | 0.82 | NR1I2 (0.43) | TP53MAPTMMP1MMP2MMP9 | |
| SCHEMBL3612848 | 0.79 | XIAP (0.47) | TP53MAPTCYP3A4CYP2D6HTT | |
| SCHEMBL4235842 | 0.77 | ACE (0.51) | MAPTMMP1MMP2MMP9MMP12 | |
| SCHEMBL3607627 | 0.75 | ACE (0.47) | TP53MAPTHTTLMNASMN1; SMN2 | |
| SCHEMBL3612560 | 0.75 | MAPT (0.41) | TP53MAPTHTTLMNASMN1; SMN2 | |
| SCHEMBL3607354 | 0.74 | ACE (0.46) | TP53MAPTHTTLMNASMN1; SMN2 | |
| SCHEMBL3609009 | 0.74 | XIAP (0.42) | MEN1KMT2AALDH1A1 | |
| SCHEMBL3609300 | 0.73 | OPRD1 (0.55) | HTTLMNASMN1; SMN2NPSR1 | |
| SCHEMBL3605762 | 0.73 | XIAP (0.42) | TP53MAPTHTTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100022582-A1 | Tetrahydroisoquinoline Compound and Medicinal Use Thereof | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2010-01-28 | — | — | US | disclosed |
| EP-1857444-A1 | TETRAHYDROISOQUINOLINE COMPOUND AND MEDICINAL USE THEREOF | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2007-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022582-A1 | Tetrahydroisoquinoline Compound and Medicinal Use Thereof | ACAT1, ACAT2, LCAT | TP53 1800/4885MAPT 260/4885MMP1 3356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.