Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | CASP6 | P55212 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.45 |
| ▸ | CSNK2A3 | Q8NEV1 | 2/20 | 0.45 |
| ▸ | GPR35 | Q9HC97 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16555392 | 0.86 | SMN1; SMN2 (0.56) | SMN1; SMN2HPGDTP53TSHRHIF1A | |
| SCHEMBL20634962 | 0.79 | ALDH1A1 (0.44) | SMN1; SMN2HPGDTP53TSHRHIF1A | |
| SCHEMBL30042374 | 0.79 | ALDH1A1 (0.44) | SMN1; SMN2HPGDTP53TSHRHIF1A | |
| SCHEMBL29690461 | 0.77 | TXNRD1 (0.42) | SMN1; SMN2HPGDTP53TSHRCYP3A4 | |
| SCHEMBL18353017 | 0.77 | TXNRD1 (0.42) | SMN1; SMN2HPGDTP53TSHRCYP3A4 | |
| SCHEMBL31177224 | 0.77 | TP53 (0.53) | SMN1; SMN2HPGDTP53TSHRHIF1A | |
| SCHEMBL9404841 | 0.77 | TP53 (0.53) | SMN1; SMN2HPGDTP53TSHRHIF1A | |
| SCHEMBL3607301 | 0.76 | ALDH1A1 (0.65) | HPGDCYP3A4MAPTALDH1A1ALOX15 | |
| SCHEMBL16445887 | 0.72 | GPR35 (0.46) | SMN1; SMN2HPGDTP53TSHRHIF1A | |
| SCHEMBL28960887 | 0.72 | HIF1A (0.43) | SMN1; SMN2HPGDTP53TSHRHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1553074-B1 | FUSED BENZENE DERIVATIVE AND USE | TAKEDA PHARMACEUTICAL (JP) | 2014-06-18 | — | — | EP | disclosed |
| US-7649001-B2 | Fused benzene derivative and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-01-19 | — | — | US | disclosed |
| US-20060106067-A1 | Fused benzene derivative and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-05-18 | — | — | US | disclosed |
| EP-1553074-A1 | FUSED BENZENE DERIVATIVE AND USE | Takeda Pharmaceutical Company Limited (JP) | 2005-07-13 | — | — | EP | disclosed |
| US-4322414-A | MITICIDES; APHIDICIDES; LARVICIDES | VELSICOL CHEMICAL CORPORATION (US) | 1982-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106067-A1 | Fused benzene derivative and use | AR, NR5A1, CBR3 | SMN1; SMN2 4057/4885HPGD 1006/4885TP53 1985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.