Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
| ▸ | GHSR | Q92847 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3613464 | 1.00 | ADORA1 (0.54) | ADORA1PTGS2GHSRRAB9AALDH1A1 | |
| SCHEMBL3601639 | 1.00 | ADORA1 (0.54) | ADORA1PTGS2GHSRRAB9AALDH1A1 | |
| SCHEMBL3602793 | 0.87 | PTGS2 (0.52) | PTGS2GHSRRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL3605641 | 0.87 | PTGS2 (0.52) | PTGS2GHSRRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL3602791 | 0.87 | PTGS2 (0.52) | PTGS2GHSRRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL15506889 | 0.85 | ADORA1 (0.68) | ADORA1PTGS2RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL3604137 | 0.80 | ADORA1 (0.56) | ADORA1PTGS2GHSRRAB9AALDH1A1 | |
| SCHEMBL3609782 | 0.80 | ADORA1 (0.56) | ADORA1PTGS2GHSRRAB9AALDH1A1 | |
| SCHEMBL3598892 | 0.80 | ADORA1 (0.56) | ADORA1PTGS2GHSRRAB9AALDH1A1 | |
| SCHEMBL3613589 | 0.80 | MAOA (0.48) | PTGS2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | claimed |
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | IDO2, IDO1, INMT | ADORA1 407/4885PTGS2 356/4885GHSR 2639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.