Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 17/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 17/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 17/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.32 |
| ▸ | GABRE | P78334 | 1/20 | 0.32 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.32 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.32 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.32 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3870835 | 0.72 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3576327 | 0.67 | GABRG2 (0.65) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3872216 | 0.64 | GABRG2 (0.68) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL2426577 | 0.64 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3874686 | 0.63 | GABRG2 (0.74) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3870299 | 0.63 | GABRG2 (0.74) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL5821397 | 0.60 | GABRG2 (0.64) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3871909 | 0.60 | GABRG2 (0.68) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3571674 | 0.59 | GABRG2 (0.72) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3871361 | 0.59 | GABRG2 (0.64) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7671048-B2 | Substituted imidazo [1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-03-02 | — | — | US | disclosed |
| US-20060079507-A1 | Substituted imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine derivatives | HOFFMANN-LA ROCHE INC. | 2006-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079507-A1 | Substituted imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine derivatives | GABRA3, GABRA1, OXER1 | GABRG2 73/4885GABRB3 10/4885GABRA5 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.