SCHEMBL3602169

SCHEMBL3602169

N=C(NC(=O)O)NC(N)=S

nearest known ligand 0.44

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TAS2R38 P59533 1/20 0.44
ALDH1A1 P00352 3/20 0.39
HTT P42858 1/20 0.33
HSD17B10 Q99714 2/20 0.30
PTGS2 P35354 1/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL857557 0.81
SCHEMBL18557571 0.81 KDM5B (0.33)
SCHEMBL23061339 0.78 TAS2R38 (0.68) TAS2R38ALDH1A1
Bicarbonate SCHEMBL10653459 0.74 TAS2R38 (0.48) TAS2R38ALDH1A1HTTHSD17B10PTGS2
Thioacetamide SCHEMBL8346695 0.74 TAS2R38 (0.62) TAS2R38ALDH1A1HTTHSD17B10PTGS2
Oxalic Acid SCHEMBL5458052 0.72 TAS2R38 (0.46) TAS2R38ALDH1A1HTTHSD17B10PTGS2
SCHEMBL8658374 0.70
SCHEMBL29006037 0.70
Acetic Acid SCHEMBL28266501 0.70 TAS2R38 (0.56) TAS2R38ALDH1A1HTTHSD17B10PTGS2
SCHEMBL1715952 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200140460-A1 ANTIBACTERIAL THERAPEUTICS AND PROPHYLACTICS VYOME BIOSCIENCES PVT. LTD. (IN) 2020-05-07 US disclosed
US-10570152-B2 Antibacterial therapeutics and prophylactics VYOME THERAPEUTICS LIMITED (IN) 2020-02-25 US disclosed
US-20180265523-A1 ANTIBACTERIAL THERAPEUTICS AND PROPHYLACTICS VYOME THERAPEUTICS LIMITED (IN) 2018-09-20 US disclosed
EP-3328856-A2 ANTIBACTERIAL THERAPEUTICS AND PROPHYLACTICS Vyome Biosciences Pvt. Ltd. (IN) 2018-06-06 EP disclosed
WO-2017017631-A2 ANTIBACTERIAL THERAPEUTICS AND PROPHYLACTICS VYOME BIOSCIENCES PVT. LTD. (IN) 2017-02-02 WO disclosed
US-20100298340-A1 Thiazol-Guanidine Derivatives Useful As A (Beta)-Related Pathologies ASTRAZENECA AB (SE) 2010-11-25 US disclosed
EP-2010508-A1 THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES AstraZeneca AB (SE) 2009-01-07 EP disclosed
WO-2007120096-A1 THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES ASTRAZENECA AB (SE) 2007-10-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100298340-A1 Thiazol-Guanidine Derivatives Useful As A (Beta)-Related Pathologies GRN, MAPT, GUCY1B1 TAS2R38 564/4885ALDH1A1 1302/4885HTT 105/4885
US-20180265523-A1 ANTIBACTERIAL THERAPEUTICS AND PROPHYLACTICS CLPP, CFTR, ELANE TAS2R38 3236/4885ALDH1A1 4010/4885HTT 4112/4885
US-20200140460-A1 ANTIBACTERIAL THERAPEUTICS AND PROPHYLACTICS CLPP, CFTR, ELANE TAS2R38 3236/4885ALDH1A1 4010/4885HTT 4112/4885
US-10570152-B2 Antibacterial therapeutics and prophylactics CLPP, CFTR, ELANE TAS2R38 3236/4885ALDH1A1 4010/4885HTT 4112/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.