Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3599589 | 0.99 | HRH3 (0.56) | HRH3KCNH2HRH4HRH1 | |
| SCHEMBL3597755 | 0.97 | HRH3 (0.52) | HRH3KCNH2HRH4HRH1MEN1 | |
| SCHEMBL3594803 | 0.96 | HRH3 (0.51) | HRH3KCNH2HRH4HRH1MEN1 | |
| SCHEMBL3599212 | 0.92 | CYP1A2 (0.54) | HRH3KCNH2HRH1MEN1KMT2A | |
| SCHEMBL3604671 | 0.84 | SLC2A2 (0.55) | MEN1KMT2ASLC2A1 | |
| SCHEMBL3594668 | 0.83 | HTR1A (0.57) | HRH3KCNH2HRH1 | |
| SCHEMBL3600202 | 0.81 | MEN1 (0.54) | MEN1KMT2A | |
| SCHEMBL5053629 | 0.80 | CYP1A2 (0.47) | MEN1KMT2A | |
| SCHEMBL3602109 | 0.79 | HRH3 (0.50) | HRH3KCNH2HRH4HRH1 | |
| SCHEMBL3605027 | 0.79 | SLC2A2 (0.58) | MEN1KMT2ASLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097392-B1 | 1,2,3-TRIAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | ESTEVE LABOR DR (ES) | 2013-03-13 | — | — | EP | claimed |
| US-8193223-B2 | 1,2,3-triazole derivatives as sigma receptor inhibitors | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-06-05 | — | — | US | claimed |
| US-20100004265-A1 | 1,2,3-TRIAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | LABORATORIOS DEL DR. ESTEVE, S.A. | 2010-01-07 | — | — | US | claimed |
| EP-2097392-A1 | 1,2,3-TRIAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-09-09 | — | — | EP | claimed |
| WO-2008055933-A1 | 1,2,3-TRIAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-05-15 | — | — | WO | claimed |
| EP-1921071-A1 | 1,2,3- triazole derivatives as sigma receptor inhibitors | Laboratorios del Dr. Esteve S.A. (ES) | 2008-05-14 | — | — | EP | claimed |
| EP-2097392-B1 | 1,2,3-TRIAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | ESTEVE LABOR DR (ES) | 2013-03-13 | — | — | EP | disclosed |
| US-8193223-B2 | 1,2,3-triazole derivatives as sigma receptor inhibitors | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-06-05 | — | — | US | disclosed |
| US-20100004265-A1 | 1,2,3-TRIAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | LABORATORIOS DEL DR. ESTEVE, S.A. | 2010-01-07 | — | — | US | disclosed |
| EP-2097392-A1 | 1,2,3-TRIAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008055933-A1 | 1,2,3-TRIAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-05-15 | — | — | WO | disclosed |
| EP-1921071-A1 | 1,2,3- triazole derivatives as sigma receptor inhibitors | Laboratorios del Dr. Esteve S.A. (ES) | 2008-05-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004265-A1 | 1,2,3-TRIAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | SIGMAR1, OPRK1, OPRD1 | HRH3 244/4885KCNH2 623/4885HRH4 325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.