SCHEMBL3604533

SCHEMBL3604533

Cc1ccc(-n2ccnc2C)nc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.49
CYP2E1 P05181 1/20 0.49
CYP2A6 P11509 1/20 0.49
TUBB4A P04350 2/20 0.47
TUBB P07437 2/20 0.47
TUBA3C P0DPH7 2/20 0.47
TUBA1B P68363 2/20 0.47
TUBA4A P68366 2/20 0.47
TUBB4B P68371 2/20 0.47
TUBB3 Q13509 2/20 0.47
TUBB2A Q13885 2/20 0.47
TUBB8 Q3ZCM7 2/20 0.47
TUBA3E Q6PEY2 2/20 0.47
TUBA1A Q71U36 2/20 0.47
TUBA1C Q9BQE3 2/20 0.47
TUBB6 Q9BUF5 2/20 0.47
TUBB2B Q9BVA1 2/20 0.47
TUBB1 Q9H4B7 2/20 0.47
KDR P35968 1/20 0.44
ALDH1A1 P00352 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2065882 0.81 CYP3A4 (0.46) CYP3A4CYP2E1CYP2A6TUBB4ATUBB
SCHEMBL3745779 0.81 CYP3A4 (0.46) CYP3A4CYP2E1CYP2A6TUBB4ATUBB
SCHEMBL24240217 0.79 CYP3A4 (0.50) CYP3A4CYP2E1CYP2A6TUBB4ATUBB
SCHEMBL27473377 0.79 CYP3A4 (0.44) CYP3A4CYP2E1CYP2A6TUBB4ATUBB
SCHEMBL14923458 0.79 TUBB4A (0.46) CYP3A4CYP2E1CYP2A6TUBB4ATUBB
SCHEMBL13466401 0.79 CYP3A4 (0.44) CYP3A4CYP2E1CYP2A6TUBB4ATUBB
SCHEMBL14761507 0.78 LMNA (0.44) CYP3A4CYP2E1CYP2A6TUBB4ATUBB
SCHEMBL14761942 0.78 ALDH1A1 (0.64) CYP3A4CYP2E1CYP2A6TUBB4ATUBB
SCHEMBL1462555 0.78 LMNA (0.44) CYP3A4CYP2E1CYP2A6TUBB4ATUBB
SCHEMBL1757027 0.76 LMNA (0.54) CYP3A4CYP2E1CYP2A6ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024145483-A1 COMPOUNDS FOR USE IN THE TREATMENT OF CANCER AND METHODS OF MAKING AND USING THE SAME HTG MOLECULAR DIAGNOSTICS, INC. (US) 2024-07-04 WO disclosed
US-20140288044-A1 COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS ALZHEIMER'S INSTITUTE OF AMERICA, INC. (US) 2014-09-25 US disclosed
US-8293916-B2 Diazole derivatives HOFFMANN-LA ROCHE INC. (US) 2012-10-23 US disclosed
CN-1960984-B Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as MGLU5 receptor antagonists HOFFMANN LA ROCHE 2010-05-12 CN disclosed
US-20100048569-A1 DIAZOLE DERIVATIVES BUETTELMANN BERND 2010-02-25 US disclosed
EP-1756086-B1 PYRIDIN-4-YL-ETHYNYL-IMIDAZOLES AND PYRAZOLES AS MGLU5 RECEPTOR ANTAGONISTS HOFFMANN LA ROCHE (CH) 2008-06-04 EP disclosed
CN-1960984-A Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as MGLU5 receptor antagonists HOFFMANN LA ROCHE (CH) 2007-05-09 CN disclosed
EP-1756086-A1 PYRIDIN-4-YL-ETHYNYL-IMIDAZOLES AND PYRAZOLES AS MGLU5 RECEPTOR ANTAGONISTS F.HOFFMANN-LA ROCHE AG (CH) 2007-02-28 EP disclosed
US-20060030559-A1 Diazole derivatives F. HOFFMANN-LA ROCHE AG (CH) 2006-02-09 US disclosed
WO-2005118568-A1 PYRIDIN-4-YL-ETHYNYL-IMIDAZOLES AND PYRAZOLES AS MGLU5 RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2005-12-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100048569-A1 DIAZOLE DERIVATIVES GRM1, GRM2, GRIN2B CYP3A4 2929/4885CYP2E1 1686/4885CYP2A6 4009/4885
US-20060030559-A1 Diazole derivatives GRM1, GRM2, GRIN2B CYP3A4 2929/4885CYP2E1 1686/4885CYP2A6 4009/4885
US-20140288044-A1 COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS CSNK1G1, PRKCE, PHKG1 CYP3A4 4808/4885CYP2E1 4366/4885CYP2A6 4733/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.