Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9016703 | 0.90 | MAPT (0.41) | MEN1KMT2AKDM4EMAPTLMNA | |
| SCHEMBL8155555 | 0.86 | KDM4E (0.42) | MEN1KMT2AKDM4EMAPTLMNA | |
| SCHEMBL8136234 | 0.84 | KDM4E (0.52) | MEN1KMT2AKDM4EMAPTMAPK1 | |
| SCHEMBL30958584 | 0.78 | ALDH1A1 (0.44) | MEN1KMT2AKDM4EMAPTLMNA | |
| SCHEMBL1185918 | 0.78 | ALDH1A1 (0.44) | MEN1KMT2AKDM4EMAPTLMNA | |
| SCHEMBL10511114 | 0.76 | CHEK1 (0.39) | MAPTLMNAMAPK1CASP1CASP7 | |
| SCHEMBL9469723 | 0.76 | KDM4E (0.47) | MEN1KMT2AKDM4EMAPTLMNA | |
| SCHEMBL6798131 | 0.75 | ALDH1A1 (0.50) | MEN1KMT2AKDM4EMAPTLMNA | |
| SCHEMBL10512661 | 0.74 | CHEK1 (0.38) | MEN1KMT2AMAPTLMNAMAPK1 | |
| SCHEMBL10516112 | 0.74 | ALDH1A1 (0.41) | MEN1KMT2AKDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675880-B1 | QUINOLINE DISULFIDES AS INTERMEDIATES | ARCHIMICA SPA (IT) | 2000-01-05 | — | — | EP | claimed |
| EP-0675880-A1 | QUINILONE DISULFIDE AS INTERMEDIATES | ARCHIMICA S.P.A. (IT) | 1995-10-11 | — | — | EP | claimed |
| WO-1995011886-A1 | QUINILONE DISULFIDE AS INTERMEDIATES | ARCHIMICA S.P.A. (IT) | 1995-05-04 | — | — | WO | claimed |
| US-5221741-A | Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1993-06-22 | — | — | US | claimed |
| EP-0522277-A1 | Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride | MEDIOLANUM FARMACEUTICI s.r.l. (IT) | 1993-01-13 | — | — | EP | claimed |
| JP-5194535-A | — | — | None | — | — | JP | disclosed |
| US-20100029938-A1 | PROCESS FOR THE PREPARATION OF AN ANTIBACTERIAL QUINOLONE COMPOUND | FARMAPROJECTS, S. A. (ES) | 2010-02-04 | — | — | US | disclosed |
| WO-2008077643-A1 | PROCESS FOR THE PREPARATION OF AN ANTIBACTERIAL QUINOLONE COMPOUND | FARMAPROJECTS, S.A. (ES) | 2008-07-03 | — | — | WO | disclosed |
| EP-1939206-A1 | Process for the preparation of an antibacterial quinolone compound | Farmaprojects, S.A. (ES) | 2008-07-02 | — | — | EP | disclosed |
| EP-0675880-B1 | QUINOLINE DISULFIDES AS INTERMEDIATES | ARCHIMICA SPA (IT) | 2000-01-05 | — | — | EP | disclosed |
| US-5731433-A | Process for the preparation of rufloxacin and salts thereof | ARCHIMICA SPA (IT) | 1998-03-24 | — | — | US | disclosed |
| US-5703233-A | Quinilone disulfide as intermediates | ARCHIMICA SPA (IT) | 1997-12-30 | — | — | US | disclosed |
| EP-0675880-A1 | QUINILONE DISULFIDE AS INTERMEDIATES | ARCHIMICA S.P.A. (IT) | 1995-10-11 | — | — | EP | disclosed |
| WO-1995011907-A1 | PROCESS FOR THE PREPARATION OF RUFLOXACIN AND SALTS THEREOF | ARCHIMICA S.P.A. (IT) | 1995-05-04 | — | — | WO | disclosed |
| WO-1995011886-A1 | QUINILONE DISULFIDE AS INTERMEDIATES | ARCHIMICA S.P.A. (IT) | 1995-05-04 | — | — | WO | disclosed |
| JP-H05194535-A | PRODUCTION OF 9-FLUORO-10-(4-METHYL-1-PIPERAZINYL)-7-OXO-2,3-DIHYDRO-7H-PYRIDO(1,2,3-DE)(1,4)BENZOTHIAZINE-6-CARBOXYLIC ACID HYDROCHLORIDE | MEDIOLANUM FARMACEUT SRL | 1993-08-03 | — | — | JP | disclosed |
| US-5221741-A | Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1993-06-22 | — | — | US | disclosed |
| US-5221741-A | Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1993-06-22 | — | — | US | disclosed |
| EP-0522277-A1 | Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride | MEDIOLANUM FARMACEUTICI s.r.l. (IT) | 1993-01-13 | — | — | EP | disclosed |
| EP-0522277-A1 | Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride | MEDIOLANUM FARMACEUTICI s.r.l. (IT) | 1993-01-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029938-A1 | PROCESS FOR THE PREPARATION OF AN ANTIBACTERIAL QUINOLONE COMPOUND | CYP3A4, CYP4B1, CYP4F11 | MEN1 3155/4885KMT2A 3906/4885KDM4E 998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.