Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1186952 | 0.79 | ALDH1A1 (0.45) | KDM4EKMT2AMAPK1LMNAMAPT | |
| SCHEMBL3606905 | 0.76 | MEN1 (0.47) | KDM4EMEN1KMT2AMAPK1LMNA | |
| SCHEMBL8136234 | 0.74 | KDM4E (0.52) | KDM4EMEN1KMT2AMAPK1MAPT | |
| SCHEMBL8120918 | 0.73 | KDM4E (0.49) | KDM4EMEN1KMT2AMAPK1LMNA | |
| SCHEMBL6798131 | 0.72 | ALDH1A1 (0.50) | KDM4EMEN1KMT2ALMNAMAPT | |
| SCHEMBL8138598 | 0.72 | ALDH1A1 (0.47) | KDM4EMAPK1LMNAMAPTCASP1 | |
| SCHEMBL9824312 | 0.71 | ALDH1A1 (0.40) | KDM4EKMT2AMAPK1LMNAMAPT | |
| SCHEMBL9824894 | 0.71 | ALDH1A1 (0.40) | KDM4EMAPK1LMNAMAPTCASP1 | |
| SCHEMBL8155555 | 0.70 | KDM4E (0.42) | KDM4EMEN1KMT2AMAPK1LMNA | |
| SCHEMBL28499259 | 0.70 | CES2 (0.48) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5221741-A | Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1993-06-22 | — | — | US | claimed |
| EP-0522277-A1 | Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride | MEDIOLANUM FARMACEUTICI s.r.l. (IT) | 1993-01-13 | — | — | EP | claimed |
| JP-5194535-A | — | — | None | — | — | JP | disclosed |
| JP-H05194535-A | PRODUCTION OF 9-FLUORO-10-(4-METHYL-1-PIPERAZINYL)-7-OXO-2,3-DIHYDRO-7H-PYRIDO(1,2,3-DE)(1,4)BENZOTHIAZINE-6-CARBOXYLIC ACID HYDROCHLORIDE | MEDIOLANUM FARMACEUT SRL | 1993-08-03 | — | — | JP | disclosed |
| US-5221741-A | Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1993-06-22 | — | — | US | disclosed |
| US-5221741-A | Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1993-06-22 | — | — | US | disclosed |
| EP-0522277-A1 | Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride | MEDIOLANUM FARMACEUTICI s.r.l. (IT) | 1993-01-13 | — | — | EP | disclosed |
| EP-0522277-A1 | Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride | MEDIOLANUM FARMACEUTICI s.r.l. (IT) | 1993-01-13 | — | — | EP | disclosed |