Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 10/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.43 |
| ▸ | CYP2E1 | P05181 | 5/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19745884 | 0.86 | CYP2A6 (0.56) | KDM4ESMN1; SMN2CYP2A6CYP2C9CYP2C19 | |
| SCHEMBL1424931 | 0.79 | KDM4E (0.75) | KDM4ESMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL3607989 | 0.79 | RAB9A (0.58) | KDM4ESMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL3608623 | 0.75 | CHRNB2 (0.54) | KDM4ESMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL2460752 | 0.73 | CHRNB2 (0.58) | KDM4ESMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL12278703 | 0.73 | KDM4E (0.66) | KDM4ESMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL255577 | 0.70 | KDM4E (0.66) | KDM4ESMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL30803985 | 0.70 | KDM4E (0.66) | KDM4ESMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL970073 | 0.68 | KDM4E (0.64) | KDM4ESMN1; SMN2RAB9ANPC1MEN1 | |
| Bromide SCHEMBL162182 | 0.68 | KDM4E (0.64) | KDM4ESMN1; SMN2RAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029685-A1 | OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2010-02-04 | — | — | US | claimed |
| CN-101553486-A | Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators | NEUROSEARCH AS (DK) | 2009-10-07 | — | — | CN | claimed |
| EP-2079734-A1 | OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NeuroSearch A/S (DK) | 2009-07-22 | — | — | EP | claimed |
| WO-2008049864-A1 | OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2008-05-02 | — | — | WO | claimed |
| US-20100029685-A1 | OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2010-02-04 | — | — | US | disclosed |
| CN-101553486-A | Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators | NEUROSEARCH AS (DK) | 2009-10-07 | — | — | CN | disclosed |
| EP-2079734-A1 | OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NeuroSearch A/S (DK) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008049864-A1 | OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2008-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029685-A1 | OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | CHRNA3, CHRNA5, CHRNB3 | KDM4E 3713/4885SMN1; SMN2 274/4885RAB9A 3855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.