Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3945936 | 0.88 | KDM4E (0.38) | ADORA3ADORA2AADORA2BADORA1MEN1 | |
| SCHEMBL8115931 | 0.81 | MAPT (0.36) | ADORA3ADORA2AADORA2BADORA1MAPT | |
| SCHEMBL4331572 | 0.79 | P4HTM (0.53) | MEN1KMT2AKDM4EMAPTTDP1 | |
| SCHEMBL5371986 | 0.79 | ALDH1A1 (0.44) | ADORA3MEN1KMT2AKDM4ELMNA | |
| SCHEMBL2656296 | 0.78 | CYP1A2 (0.49) | MEN1KMT2AKDM4EMAPTTDP1 | |
| SCHEMBL5383142 | 0.78 | PLOD2 (0.43) | ADORA3ADORA2AADORA2BADORA1MEN1 | |
| SCHEMBL2901448 | 0.76 | P4HTM (0.37) | MEN1KMT2AKDM4EMAPTTDP1 | |
| SCHEMBL13341653 | 0.76 | ALDH1A1 (0.44) | MEN1KMT2AKDM4EMAPTTDP1 | |
| SCHEMBL2643085 | 0.76 | TDP1 (0.48) | ADORA3MEN1KMT2AKDM4EMAPT | |
| SCHEMBL17666650 | 0.76 | HSP90AB1 (0.44) | MEN1KMT2AKDM4EMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029668-A1 | NOVEL PYRIDAZINE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-02-04 | — | — | US | disclosed |
| EP-2049521-A2 | NOVEL PYRIDAZINE DERIVATIVES | Syngeta Participations AG (CH) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008009405-A2 | NOVEL PYRIDAZINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029668-A1 | NOVEL PYRIDAZINE DERIVATIVES | C3AR1, C5, C1S | ADORA3 1257/4885ADORA2A 2011/4885ADORA2B 2877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.