Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.35 |
| ▸ | STK17B | O94768 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4331572 | 0.84 | P4HTM (0.53) | ALDH1A1L3MBTL1LMNAP4HA1MIF | |
| SCHEMBL2901448 | 0.81 | P4HTM (0.37) | ALDH1A1L3MBTL1LMNAPLK1P4HA1 | |
| SCHEMBL3608608 | 0.79 | ADORA3 (0.40) | ALDH1A1L3MBTL1LMNAPLK1P4HTM | |
| SCHEMBL29694969 | 0.79 | MAPK1 (0.61) | ALDH1A1L3MBTL1HPGDLMNAPLK1 | |
| SCHEMBL5211462 | 0.79 | MAPK1 (0.61) | ALDH1A1L3MBTL1HPGDLMNAPLK1 | |
| SCHEMBL13562370 | 0.79 | ALDH1A1 (0.40) | ALDH1A1KCNJ1L3MBTL1HPGDLMNA | |
| SCHEMBL3613594 | 0.77 | PCSK9 (0.36) | ALDH1A1PLK1P4HA1MIFP4HTM | |
| SCHEMBL2656296 | 0.75 | CYP1A2 (0.49) | ALDH1A1LMNAMAPK1KDM4EMEN1 | |
| SCHEMBL22583226 | 0.74 | PRMT1 (0.41) | KDM4ENOS3NOS1KMT2A | |
| SCHEMBL26401202 | 0.74 | ALDH1A1 (0.43) | ALDH1A1KCNJ1L3MBTL1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235560-B2 | Pyrimidine derivative as selective COX-2 inhibitors | GLAXO GROUP LIMITED (GB) | 2007-06-26 | — | — | US | disclosed |
| US-7235560-B2 | Pyrimidine derivative as selective COX-2 inhibitors | GLAXO GROUP LIMITED (GB) | 2007-06-26 | — | — | US | disclosed |
| US-7235560-B2 | Pyrimidine derivative as selective COX-2 inhibitors | GLAXO GROUP LIMITED (GB) | 2007-06-26 | — | — | US | disclosed |
| EP-1546128-B1 | PYRIMIDINE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LTD (GB) | 2006-05-03 | — | — | EP | disclosed |
| US-20060040967-A1 | Pyrimidine derivative as selelctive cox-2 inhibitors | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | US | disclosed |
| EP-1546128-A1 | PYRIMIDINE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004018452-A1 | PYRIMIDINE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040967-A1 | Pyrimidine derivative as selelctive cox-2 inhibitors | PTGES2, PTGS2, DPYD | ALDH1A1 422/4885KCNJ1 2032/4885L3MBTL1 4739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.