Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | RRM1 | P23921 | 2/20 | 0.50 |
| ▸ | RRM2B | Q7LG56 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11091588 | 0.89 | MAPT (0.55) | MAPTRAB9ANPC1GAANPSR1 | |
| SCHEMBL11085002 | 0.88 | ABL1 (0.49) | MAPTRAB9ANPC1GAANPSR1 | |
| SCHEMBL3603750 | 0.88 | MAPT (0.55) | MAPTRAB9ANPC1GAANPSR1 | |
| SCHEMBL3606683 | 0.86 | CSNK2A1 (0.58) | PHGDHMAPTRAB9ANPC1GAA | |
| SCHEMBL10743494 | 0.86 | PHGDH (0.53) | PHGDHMAPTRAB9ANPC1GAA | |
| SCHEMBL10743499 | 0.86 | PHGDH (0.53) | PHGDHMAPTRAB9ANPC1GAA | |
| SCHEMBL11087776 | 0.86 | ALDH1A1 (0.56) | MAPTRAB9ANPC1GAANPSR1 | |
| Bromide SCHEMBL7142457 | 0.85 | CSNK2A1 (0.57) | PHGDHMAPTRAB9ANPC1GAA | |
| SCHEMBL11090239 | 0.85 | MAPT (0.51) | MAPTRAB9ANPC1GAANPSR1 | |
| SCHEMBL11248461 | 0.84 | MAPT (0.55) | MAPTRAB9ANPC1GAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298340-A1 | Thiazol-Guanidine Derivatives Useful As A (Beta)-Related Pathologies | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | claimed |
| US-20100298340-A1 | Thiazol-Guanidine Derivatives Useful As A (Beta)-Related Pathologies | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | disclosed |
| US-4696933-A | INHIBIT GASTRIC ACID SECRETION | ICI AMERICAS INC. (GB) | 1987-09-29 | — | — | US | disclosed |
| US-4496564-A | HISTAMINE H-2 ANTIGONISTS | ICI AMERICAS INC. (US) | 1985-01-29 | — | — | US | disclosed |
| EP-0060093-A2 | Amide derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-09-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298340-A1 | Thiazol-Guanidine Derivatives Useful As A (Beta)-Related Pathologies | GRN, MAPT, GUCY1B1 | PHGDH 1989/4885MAPT 2/4885RAB9A 1024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.