Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3612360 | 0.86 | SMN1; SMN2 (0.51) | SMN1; SMN2SIRT1LMNAGABRA5GABRB2 | |
| SCHEMBL307293 | 0.76 | SMN1; SMN2 (1.00) | SMN1; SMN2SIRT1LMNAGABRA5GABRB2 | |
| Hydrochloric Acid SCHEMBL3606873 | 0.75 | SMN1; SMN2 (0.97) | SMN1; SMN2SIRT1LMNAGABRA5GABRB2 | |
| SCHEMBL15974385 | 0.74 | ALDH1A1 (0.40) | GRM2CYP11B2JAK2RORCPRMT5 | |
| SCHEMBL79013 | 0.69 | GRM2 (0.43) | LMNAGRM2CYP11B2PIK3CAMTOR | |
| SCHEMBL31234993 | 0.69 | PRMT5 (0.36) | GRM2CYP11B2PIK3CAMTORJAK2 | |
| Trifluoroacetic Acid SCHEMBL465779 | 0.69 | SMN1; SMN2 (0.75) | SMN1; SMN2SIRT1LMNAGABRA5GABRB2 | |
| SCHEMBL25284273 | 0.68 | HTT (0.57) | SMN1; SMN2LMNAHSD17B10MAPTPRMT5 | |
| SCHEMBL3624985 | 0.68 | SMN1; SMN2 (0.72) | SMN1; SMN2LMNAGABRA5GABRB2HSD17B10 | |
| SCHEMBL2111372 | 0.68 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNAGABRA5GABRB2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113435-A1 | INHIBITORS OF 11-BETA-HYDROXY STERIOD DEHYDROGENASE TYPE 1 | BIOVITRUM AB | 2010-05-06 | — | — | US | disclosed |
| US-7618961-B2 | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | BIOVITRUM AB (SE) | 2009-11-17 | — | — | US | disclosed |
| US-20040224996-A1 | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | BIOVITRUM AB (SE) | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224996-A1 | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | HSD11B1, HSD17B1, HSD11B2 | SMN1; SMN2 3226/4885SIRT1 1127/4885LMNA 1833/4885 |
| US-20100113435-A1 | INHIBITORS OF 11-BETA-HYDROXY STERIOD DEHYDROGENASE TYPE 1 | HSD11B1, HSD17B1, HSD3B1 | SMN1; SMN2 3799/4885SIRT1 1168/4885LMNA 3439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.