Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.64 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.64 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.64 |
| ▸ | F7 | P08709 | 1/20 | 0.64 |
| ▸ | F3 | P13726 | 1/20 | 0.64 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.64 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.64 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.64 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | ALPL | P05186 | 1/20 | 0.54 |
| ▸ | ALPI | P09923 | 1/20 | 0.54 |
| ▸ | ALPG | P10696 | 1/20 | 0.54 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18136526 | 0.85 | HDAC1 (0.65) | SIRT2SIRT1SIRT3F7F3 | |
| SCHEMBL5361880 | 0.85 | HDAC1 (0.74) | SIRT2SIRT1SIRT3F7F3 | |
| SCHEMBL29099754 | 0.82 | LMNA (0.69) | SIRT2KMT2AKCNK3LMNAHIF1A | |
| SCHEMBL22983139 | 0.82 | KCNK3 (0.74) | SIRT2SIRT1SIRT3F7F3 | |
| SCHEMBL255625 | 0.81 | CA1 (0.65) | SIRT2SIRT1SIRT3F7F3 | |
| SCHEMBL5361922 | 0.80 | GAA (0.77) | KMT2AHDAC1HDAC6FTOGAA | |
| Hydrochloric Acid SCHEMBL872442 | 0.79 | CA1 (0.63) | SIRT2SIRT1SIRT3F7F3 | |
| Niacinamide SCHEMBL460466 | 0.79 | F7 (1.00) | SIRT2SIRT1SIRT3F7F3 | |
| Niacinamide SCHEMBL29624874 | 0.79 | — | — | |
| Niacinamide SCHEMBL19978192 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120172358-A1 | GPCR Agonists | PROSIDION LIMITED (GB) | 2012-07-05 | — | — | US | disclosed |
| US-20100063081-A1 | CPCR Agonists | PROSIDION LIMITED (GB) | 2010-03-11 | — | — | US | disclosed |
| US-20100029685-A1 | OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172358-A1 | GPCR Agonists | GPR119, GCGR, GPR27 | SIRT2 2223/4885SIRT1 1801/4885SIRT3 2260/4885 |
| US-20100063081-A1 | CPCR Agonists | GPR119, GCGR, GLP1R | SIRT2 2544/4885SIRT1 1777/4885SIRT3 2335/4885 |
| US-20100029685-A1 | OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | CHRNA3, CHRNA5, CHRNB3 | SIRT2 902/4885SIRT1 397/4885SIRT3 256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.