Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3624517 | 0.78 | KDM4E (0.32) | ALDH1A1SMN1; SMN2KDM4ELMNAMDM2 | |
| Hydrochloric Acid SCHEMBL618964 | 0.77 | KDM4E (0.31) | ALDH1A1SMN1; SMN2KDM4ELMNAMDM2 | |
| SCHEMBL3683551 | 0.76 | NPC1 (0.31) | NPC1ALDH1A1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL3256296 | 0.76 | KDM4E (0.32) | ALDH1A1SMN1; SMN2KDM4ELMNAMDM2 | |
| Hydrochloric Acid SCHEMBL394796 | 0.75 | TSHR (0.31) | TSHRLMNA | |
| Hydrochloric Acid SCHEMBL3625537 | 0.74 | HTR7 (0.34) | ALDH1A1SMN1; SMN2TDP1KDM4ELMNA | |
| SCHEMBL3684203 | 0.72 | LPAR1 (0.48) | ALDH1A1SMN1; SMN2TDP1KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL3615425 | 0.70 | MEN1 (0.33) | NPC1SMN1; SMN2TSHR | |
| SCHEMBL3686734 | 0.67 | — | — | |
| SCHEMBL22320321 | 0.66 | PTGDR2 (0.40) | NPC1TSHRKDM4ELPAR1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645715-B2 | Bis-arylaryloxy catalytic system for producing ethylene homopolymers or ethylene copolymers with alpha-olefins | SK ENERGY CO., LTD. (KR) | 2010-01-12 | — | — | US | disclosed |
| US-20070249490-A1 | BIS-ARYLARYLOXY CATALYTIC SYSTEM FOR PRODUCING ETHYLENE HOMOPOLYMERS OR ETHYLENE COPOLYMERS WITH ALPHA-OLEFINS | SK CORPORATION (KR) | 2007-10-25 | — | — | US | disclosed |