Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.32 |
| ▸ | MAOA | P21397 | 3/20 | 0.32 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3615425 | 0.82 | MEN1 (0.33) | RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3611287 | 0.72 | HTR7 (0.35) | HTR7ADRB2L3MBTL1MAPK1TDP1 | |
| Hydrochloric Acid SCHEMBL15746629 | 0.72 | KDM4E (0.31) | HTR7LMNARAB9AALDH1A1MAOA | |
| Hydrochloric Acid SCHEMBL15746625 | 0.71 | ESR1 (0.30) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL346593 | 0.71 | ADRA2A (0.34) | HTR7ADRB2L3MBTL1MAPK1TDP1 | |
| Hydrochloric Acid SCHEMBL392238 | 0.71 | — | — | |
| SCHEMBL3676430 | 0.70 | L3MBTL1 (0.35) | HTR7ADRB2L3MBTL1MAPK1TDP1 | |
| SCHEMBL370497 | 0.70 | HTR7 (0.35) | HTR7ADRB2L3MBTL1MAPK1TDP1 | |
| Hydrochloric Acid SCHEMBL3625539 | 0.69 | MAPK1 (0.36) | HTR7ADRB2L3MBTL1MAPK1TDP1 | |
| SCHEMBL22186612 | 0.67 | HTR7 (0.37) | HTR7ADRB2L3MBTL1MAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010576-B1 | BIS-ARYLARYLOXY CATALYTIC SYSTEM FOR PRODUCING ETHYLENE HOMOPOLYMERS OR ETHYLENE COPOLYMERS WITH ALPHA-OLEFINS | SK INNOVATION CO LTD (KR) | 2013-07-24 | — | — | EP | disclosed |
| US-7645715-B2 | Bis-arylaryloxy catalytic system for producing ethylene homopolymers or ethylene copolymers with alpha-olefins | SK ENERGY CO., LTD. (KR) | 2010-01-12 | — | — | US | disclosed |
| EP-2010576-A1 | BIS-ARYLARYLOXY CATALYTIC SYSTEM FOR PRODUCING ETHYLENE HOMOPOLYMERS OR ETHYLENE COPOLYMERS WITH ALPHA-OLEFINS | SK Energy Co., Ltd. (KR) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007123362-A1 | BIS-ARYLARYLOXY CATALYTIC SYSTEM FOR PRODUCING ETHYLENE HOMOPOLYMERS OR ETHYLENE COPOLYMERS WITH ALPHA-OLEFINS | SK ENERGY CO., LTD. (KR) | 2007-11-01 | — | — | WO | disclosed |
| US-20070249490-A1 | BIS-ARYLARYLOXY CATALYTIC SYSTEM FOR PRODUCING ETHYLENE HOMOPOLYMERS OR ETHYLENE COPOLYMERS WITH ALPHA-OLEFINS | SK CORPORATION (KR) | 2007-10-25 | — | — | US | disclosed |