Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3610666 | 0.90 | MAPT (0.37) | KDM4EMEN1CYP1A2GAACYP2C9 | |
| SCHEMBL3608511 | 0.86 | MAPT (0.35) | KDM4EMEN1CYP1A2GAACYP2C9 | |
| SCHEMBL3618629 | 0.82 | RPS6KB2 (0.36) | KDM4EMEN1CYP1A2GAACYP2C9 | |
| SCHEMBL4582844 | 0.81 | HSD11B1 (0.41) | KDM4EMEN1CYP1A2GAACYP2C9 | |
| SCHEMBL3614591 | 0.80 | GABRP (0.33) | ALDH1A1TSHRRAB9AHSD17B10MAPT | |
| SCHEMBL29356089 | 0.77 | MAOB (0.40) | KDM4EMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2347918 | 0.77 | MAOB (0.40) | KDM4EMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3622023 | 0.76 | KDR (0.35) | CASP1 | |
| SCHEMBL2354401 | 0.76 | MEN1 (0.35) | MEN1CYP1A2KMT2ATSHRRAB9A | |
| SCHEMBL4610692 | 0.75 | ALDH1A1 (0.37) | KDM4EMEN1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113464-A1 | NOVEL PYRIDAZINE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-05-06 | — | — | US | claimed |
| EP-2041113-A1 | NOVEL PYRIDAZINE DERIVATIVES | Syngeta Participations AG (CH) | 2009-04-01 | — | — | EP | claimed |
| WO-2008009406-A1 | NOVEL PYRIDAZINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-01-24 | — | — | WO | claimed |
| US-20100113464-A1 | NOVEL PYRIDAZINE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-05-06 | — | — | US | disclosed |
| EP-2041113-A1 | NOVEL PYRIDAZINE DERIVATIVES | Syngeta Participations AG (CH) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008009406-A1 | NOVEL PYRIDAZINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113464-A1 | NOVEL PYRIDAZINE DERIVATIVES | C3AR1, CBR3, C5 | KDM4E 2526/4885MEN1 3202/4885CYP1A2 106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.