Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | CDC25B | P30305 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | APAF1 | O14727 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TDP2 | O95551 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GALK1 | P51570 | 2/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL332780 | 0.82 | GSK3B (0.37) | KMT2AMEN1CDC25BMAPTMAOA | |
| SCHEMBL28158855 | 0.82 | GSK3B (0.37) | KMT2AMEN1CDC25BMAPTMAOA | |
| SCHEMBL7921203 | 0.70 | — | — | |
| SCHEMBL2863 | 0.69 | — | — | |
| SCHEMBL94097 | 0.69 | MEN1 (0.41) | KMT2AMEN1CDC25BMAPTMAOA | |
| SCHEMBL2515396 | 0.68 | MAOA (0.32) | KMT2AMEN1CDC25BMAPTMAOA | |
| SCHEMBL7831389 | 0.68 | — | — | |
| SCHEMBL5712063 | 0.67 | TRPA1 (0.30) | — | |
| SCHEMBL21797450 | 0.67 | PIM1 (0.38) | MAOALMNAMAPK1MAOBALDH1A1 | |
| SCHEMBL1497963 | 0.67 | CDC25B (0.42) | KMT2AMEN1CDC25BMAPTMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111132974-B | Sulfonamide carboxamide compounds | 英夫拉索姆有限公司 | 2023-11-21 | — | — | CN | claimed |
| CN-107108583-B | Indole carboxamide compounds useful as kinase inhibitors | 百时美施贵宝公司 | 2020-11-13 | — | — | CN | claimed |
| US-10604504-B2 | Indole carboxamide compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-03-31 | — | — | US | claimed |
| US-20190248760-A1 | INDOLE CARBOXAMIDE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2019-08-15 | — | — | US | claimed |
| US-20170260160-A1 | INDOLE CARBOXAMIDE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-09-14 | — | — | US | claimed |
| EP-3209656-A1 | INDOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-08-30 | — | — | EP | claimed |
| EP-3154969-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2017-04-19 | — | — | EP | claimed |
| US-20160115126-A1 | INDOLE CARBOXAMIDE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY | 2016-04-28 | — | — | US | claimed |
| WO-2015191745-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2015-12-17 | — | — | WO | claimed |
| US-20080255147-A1 | Heterocycles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED | 2008-10-16 | — | — | US | claimed |
| WO-2006130493-A2 | HETEROCYCLES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-12-07 | — | — | WO | claimed |
| US-20050272931-A1 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. | 2005-12-08 | — | — | US | claimed |
| EP-1463714-A4 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | AMGEN INC (US) | 2005-10-19 | — | — | EP | claimed |
| US-20050227986-A1 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. | 2005-10-13 | — | — | US | claimed |
| EP-1463714-A2 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | Amgen Inc. (US) | 2004-10-06 | — | — | EP | claimed |
| US-20030195201-A1 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. | 2003-10-16 | — | — | US | claimed |
| WO-2003049702-A2 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2003-06-19 | — | — | WO | claimed |
| EP-0561357-A1 | Pharmaceutical composition comprising a potassium-channel-opener and an antagonist of angiotensin-II receptors | MERCK PATENT GmbH (DE) | 1993-09-22 | — | — | EP | claimed |
| EP-0401505-A2 | Pharmaceutical composition containing a potassium channel-activator and an ace-inhibitor | MERCK PATENT GmbH (DE) | 1990-12-12 | — | — | EP | claimed |
| EP-0346724-A1 | Chroman derivates | MERCK PATENT GmbH (DE) | 1989-12-20 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272931-A1 | Vanilloid receptor ligands and their use in treatments | TRPV1, TRPV2, TRPV3 | KMT2A 3777/4885MEN1 3504/4885CDC25B 3717/4885 |
| US-20030195201-A1 | Vanilloid receptor ligands and their use in treatments | TRPV1, TRPV2, TRPV3 | KMT2A 3770/4885MEN1 3327/4885CDC25B 3926/4885 |
| US-20190248760-A1 | INDOLE CARBOXAMIDE COMPOUNDS | BTK, JAK2, BRD4 | KMT2A 1208/4885MEN1 2447/4885CDC25B 1499/4885 |
| US-20050227986-A1 | Vanilloid receptor ligands and their use in treatments | TRPV1, TRPV2, TRPV3 | KMT2A 3777/4885MEN1 3504/4885CDC25B 3717/4885 |
| US-20170260160-A1 | INDOLE CARBOXAMIDE COMPOUNDS | BTK, JAK2, BRD4 | KMT2A 1208/4885MEN1 2447/4885CDC25B 1499/4885 |
| US-20080255147-A1 | Heterocycles useful as modulators of ion channels | KCNJ2, TRPV1, KCNJ1 | KMT2A 3189/4885MEN1 1502/4885CDC25B 1700/4885 |
| US-20160115126-A1 | INDOLE CARBOXAMIDE COMPOUNDS | BTK, JAK2, BRD4 | KMT2A 1208/4885MEN1 2447/4885CDC25B 1499/4885 |
| US-10604504-B2 | Indole carboxamide compounds | BTK, JAK2, BRD4 | KMT2A 1208/4885MEN1 2447/4885CDC25B 1499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.