Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 2/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363061 | 0.91 | KCNN4 (0.34) | NR3C2SORT1 | |
| SCHEMBL364193 | 0.89 | NPC1 (0.34) | NR3C2SORT1ALDH1A1CYP3A4 | |
| SCHEMBL363549 | 0.89 | NPC1 (0.34) | NR3C2SORT1ALDH1A1CYP3A4 | |
| SCHEMBL363211 | 0.89 | NPC1 (0.34) | NR3C2SORT1ALDH1A1CYP3A4 | |
| SCHEMBL365152 | 0.87 | PTPN1 (0.33) | NR3C2 | |
| SCHEMBL363769 | 0.87 | PTPN1 (0.33) | NR3C2 | |
| SCHEMBL363020 | 0.86 | ATR (0.35) | ALDH1A1 | |
| SCHEMBL363805 | 0.85 | GPBAR1 (0.31) | — | |
| SCHEMBL364263 | 0.85 | GPBAR1 (0.31) | — | |
| SCHEMBL363702 | 0.85 | NPC1 (0.39) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |