Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363566 | 0.92 | GPBAR1 (0.37) | LMNAGAAHTTKMT2AMEN1 | |
| SCHEMBL363293 | 0.84 | GPBAR1 (0.39) | LMNAGAAHTTKMT2AMEN1 | |
| SCHEMBL1390523 | 0.84 | LMNA (0.35) | LMNAGAAHTTKMT2AMEN1 | |
| SCHEMBL1390520 | 0.84 | LMNA (0.35) | LMNAGAAHTTKMT2AMEN1 | |
| SCHEMBL362551 | 0.82 | GPBAR1 (0.38) | LMNAGAAHTTKMT2AMEN1 | |
| SCHEMBL363619 | 0.78 | GPBAR1 (0.39) | LMNAKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL363235 | 0.77 | GPBAR1 (0.51) | KMT2AMEN1CYP1A2MAPK1BRD4 | |
| SCHEMBL1389883 | 0.76 | GPBAR1 (0.39) | LMNAGAAHTTKMT2AMEN1 | |
| SCHEMBL1389884 | 0.76 | GPBAR1 (0.39) | LMNAGAAHTTKMT2AMEN1 | |
| SCHEMBL363976 | 0.73 | GPBAR1 (0.41) | LMNAKMT2AMEN1NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |