Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363976 | 0.93 | GPBAR1 (0.41) | GPBAR1EPHX2MAPK1SLC6A9MAPK14 | |
| SCHEMBL362887 | 0.91 | GPBAR1 (0.39) | GPBAR1MAPK1BRD4KMT2AALDH1A1 | |
| SCHEMBL363235 | 0.87 | GPBAR1 (0.51) | GPBAR1EPHX2MAPK1BRD4KMT2A | |
| SCHEMBL363566 | 0.86 | GPBAR1 (0.37) | GPBAR1MAPK1BRD4KMT2AALDH1A1 | |
| SCHEMBL1390040 | 0.84 | GPBAR1 (0.39) | GPBAR1MAPK1SLC6A9MAPK14SLC6A5 | |
| SCHEMBL1390044 | 0.84 | GPBAR1 (0.39) | GPBAR1MAPK1SLC6A9MAPK14SLC6A5 | |
| SCHEMBL15949059 | 0.84 | GPBAR1 (0.37) | GPBAR1EPHX2MAPK1SLC6A9MAPK14 | |
| SCHEMBL363289 | 0.83 | GPBAR1 (0.41) | GPBAR1EPHX2SLC6A9SLC6A5BRD4 | |
| SCHEMBL362281 | 0.83 | GPBAR1 (0.48) | GPBAR1EPHX2MAPK1BRD4LMNA | |
| SCHEMBL363293 | 0.82 | GPBAR1 (0.39) | GPBAR1BRD4KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | claimed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | claimed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |