Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | BCR | P11274 | 1/20 | 0.32 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.32 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3617945 | 0.83 | AOC3 (0.51) | ALDH1A1L3MBTL1TSHRMAPK1TDP1 | |
| SCHEMBL7127057 | 0.81 | ALDH1A1 (0.64) | ALDH1A1L3MBTL1TSHRMAPK1TDP1 | |
| SCHEMBL3623954 | 0.80 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1TSHRMAPK1TDP1 | |
| SCHEMBL7120793 | 0.78 | ABL1 (0.42) | TSHRCA1CA2CYP3A4PKM | |
| SCHEMBL19667841 | 0.75 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1TSHRCA1CA2 | |
| SCHEMBL7131005 | 0.72 | TUBB1 (0.50) | L3MBTL1TSHRTDP1CYP3A4 | |
| SCHEMBL16372527 | 0.72 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1CA1CA2CYP3A4 | |
| SCHEMBL15215671 | 0.72 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1MAPK1CA1CA2 | |
| SCHEMBL1818480 | 0.72 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1CA1CA2CYP3A4 | |
| SCHEMBL7120855 | 0.70 | BACE1 (0.40) | TSHRCYP3A4KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517879-B1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | MERCK SHARP & DOHME (US) | 2014-06-04 | — | — | EP | disclosed |
| US-7834062-B2 | Aminoalkylphenols, methods of using and making the same | MERCK SHARP & DOHME CORP. (US) | 2010-11-16 | — | — | US | disclosed |
| US-20090298949-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | MERCK SHARP & DOHME LLC | 2009-12-03 | — | — | US | disclosed |
| US-7589127-B2 | Aminoalkylphenols, methods of using and making the same | MERCK & CO., INC. (US) | 2009-09-15 | — | — | US | disclosed |
| EP-1517879-A4 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | MERCK & CO INC (US) | 2006-09-13 | — | — | EP | disclosed |
| US-20050234265-A1 | Aminoalkylphenols, methods of using and making the same | MERCK SHARP & DOHME LLC | 2005-10-20 | — | — | US | disclosed |
| EP-1517879-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | Merck & Co., Inc. (US) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004000783-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | MERCK & CO., INC. (US) | 2003-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298949-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | NPEPPS, PHOSPHO1, LNPEP | ALDH1A1 1120/4885L3MBTL1 1753/4885TSHR 4709/4885 |
| US-20050234265-A1 | Aminoalkylphenols, methods of using and making the same | NPEPPS, PHOSPHO1, LNPEP | ALDH1A1 1120/4885L3MBTL1 1753/4885TSHR 4709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.