SCHEMBL7127057

SCHEMBL7127057

COc1ccc(C(O)C(Cl)(Cl)Cl)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.64
TSHR P16473 1/20 0.64
MAPK1 P28482 1/20 0.64
TDP1 Q9NUW8 1/20 0.64
L3MBTL1 Q9Y468 1/20 0.64
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA7 P43166 1/20 0.46
CA9 Q16790 1/20 0.46
CA14 Q9ULX7 1/20 0.46
AOC3 Q16853 2/20 0.46
NPSR1 Q6W5P4 1/20 0.43
GABBR2 O75899 1/20 0.43
GABBR1 Q9UBS5 1/20 0.43
ACP3 P15309 1/20 0.42
SLC2A1 P11166 1/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
GAA P10253 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3623356 0.81 ALDH1A1 (0.45) ALDH1A1TSHRMAPK1TDP1L3MBTL1
SCHEMBL5824700 0.81 AOC3 (0.50) ALDH1A1TSHRMAPK1TDP1L3MBTL1
SCHEMBL2426161 0.79 GABBR2 (0.50) ALDH1A1TSHRMAPK1TDP1L3MBTL1
SCHEMBL12493635 0.79 ALDH1A1 (0.48) ALDH1A1TSHRMAPK1TDP1L3MBTL1
SCHEMBL5865854 0.79 MEN1 (0.51) ALDH1A1TSHRMAPK1TDP1L3MBTL1
SCHEMBL11361932 0.79 NQO1 (0.52) TSHRTDP1L3MBTL1MEN1KMT2A
Methoxychlor SCHEMBL4331931 0.78 MAPK1 (1.00) ALDH1A1TSHRMAPK1TDP1L3MBTL1
Methoxychlor SCHEMBL116390 0.78 MAPK1 (1.00) ALDH1A1TSHRMAPK1TDP1L3MBTL1
SCHEMBL8776729 0.78 ALDH1A1 (0.49) ALDH1A1TSHRMAPK1TDP1L3MBTL1
SCHEMBL8776722 0.78 ALDH1A1 (0.49) ALDH1A1TSHRMAPK1TDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4249015-A Preparation of organic acids and/or esters SHELL OIL COMPANY (US) 1981-02-03 US claimed
US-11570987-B2 Pesticidal compounds and methods of use NEW YORK UNIVERSITY (US) 2023-02-07 US disclosed
US-20210092950-A1 PESTICIDAL COMPOUNDS AND METHODS OF USE NEW YORK UNIVERSITY (US) 2021-04-01 US disclosed
US-20030144541-A1 Process for preparing alpha-halogenated retones RHODIA CHIMIE (FR) 2003-07-31 US disclosed
EP-1250303-A1 METHOD FOR PREPARING ALPHA-HALOGENATED KETONES RHODIA CHIMIE (FR) 2002-10-23 EP disclosed
WO-2001055067-A1 METHOD FOR PREPARING ALPHA-HALOGENATED KETONES RHODIA CHIMIE (FR) 2001-08-02 WO disclosed
CN-1006982-B SYNTHESIS OF METHOXY PVRETHRINS INST ZOOLOGY CAS (CN) 1990-02-28 CN disclosed
CN-1036949-A The synthetic method of methoxy pvrethrins ANIMAL RESEARCH INST THE CHINE (CN) 1989-11-08 CN disclosed
US-4603227-A Novel process for preparing α-(trichloromethyl)benzyl alcohols from benzaldehydes MERCK & CO., INC. (US) 1986-07-29 US disclosed
US-4544766-A HYDROLYSIS OF DICHLOROETHENYL COMPOUND OTSUKA KAGAKU YAKUHIN KABUSHIKI KAISHA (JP) 1985-10-01 US disclosed
US-4249015-A Preparation of organic acids and/or esters SHELL OIL COMPANY (US) 1981-02-03 US disclosed
US-3966824-A BIODEGRADABLE INSECTICIDES UNIVERSITY OF ILLINOIS FOUNDATION (US) 1976-06-29 US disclosed
US-3939277-A 1-(P-ALKOXYPHENYL)-1-(P-METHYLPHENYL-2,2,2-TRICHLORO-ETHANE THE UNIVERSITY OF ILLINOIS FOUNDATION (US) 1976-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210092950-A1 PESTICIDAL COMPOUNDS AND METHODS OF USE ACHE, DDT, PTMS ALDH1A1 1169/4885TSHR 2895/4885MAPK1 4348/4885
US-11570987-B2 Pesticidal compounds and methods of use ACHE, DDT, PTMS ALDH1A1 1169/4885TSHR 2895/4885MAPK1 4348/4885
US-20030144541-A1 Process for preparing alpha-halogenated retones ADH1A, ADH1C, RER1 ALDH1A1 15/4885TSHR 1088/4885MAPK1 359/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.