Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | DGKA | P23743 | 2/20 | 0.48 |
| ▸ | FAAH | O00519 | 2/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.45 |
| ▸ | PRKCA | P17252 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL51878 | 1.00 | TSHR (0.62) | TSHRALDH1A1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL7290192 | 1.00 | TSHR (0.62) | TSHRALDH1A1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL89184 | 1.00 | TSHR (0.62) | TSHRALDH1A1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL1686744 | 1.00 | TSHR (0.62) | TSHRALDH1A1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL7946850 | 1.00 | TSHR (0.62) | TSHRALDH1A1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL20398941 | 1.00 | TSHR (0.62) | TSHRALDH1A1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL1306604 | 0.98 | TSHR (0.59) | TSHRALDH1A1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL3964566 | 0.92 | NR1I2 (0.59) | TSHRALDH1A1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL23595590 | 0.86 | ALOX15 (0.80) | TSHRALDH1A1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL15457464 | 0.86 | ALOX15 (0.80) | TSHRALDH1A1CYP3A4ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| EP-2956455-B1 | IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS | NOVARTIS AG (CH) | 2017-05-17 | — | — | EP | disclosed |
| US-9604981-B2 | IP receptor agonist heterocyclic compounds | NOVARTIS AG (CH) | 2017-03-28 | — | — | US | disclosed |
| EP-2593452-B1 | IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS | NOVARTIS AG (CH) | 2017-01-18 | — | — | EP | disclosed |
| US-20150376183-A1 | IP Receptor Agonist Heterocyclic Compounds | NOVARTIS AG (CH) | 2015-12-31 | — | — | US | disclosed |
| EP-2956455-A1 | IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS | Novartis AG (CH) | 2015-12-23 | — | — | EP | disclosed |
| CN-105189500-A | IP receptor agonist heterocyclic compounds | NOVARTIS AG | 2015-12-23 | — | — | CN | disclosed |
| EP-2802584-B1 | SALTS OF AN IP RECEPTOR AGONIST | NOVARTIS AG (CH) | 2015-11-18 | — | — | EP | disclosed |
| US-9174985-B2 | Salts of 7-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid as IP receptor agonists | NOVARTIS AG (CH) | 2015-11-03 | — | — | US | disclosed |
| US-9132127-B2 | Substituted pyrido[2,3-B]pyrazines as IP receptor agonists | NOVARTIS AG (CH) | 2015-09-15 | — | — | US | disclosed |
| EP-0481311-A2 | Aminoacid derivatives | MERCK PATENT GmbH (DE) | 1992-04-22 | — | — | EP | disclosed |
| EP-0474008-A1 | Amino acid derivatives | MERCK PATENT GmbH (DE) | 1992-03-11 | — | — | EP | disclosed |
| EP-0464517-A2 | Amino acid derivatives with renin inhibiting activity | MERCK PATENT GmbH (DE) | 1992-01-08 | — | — | EP | disclosed |
| EP-0456039-A2 | Renin inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1991-11-13 | — | — | EP | disclosed |
| EP-0446751-A1 | Glycolic acid derivatives | MERCK PATENT GmbH (DE) | 1991-09-18 | — | — | EP | disclosed |
| EP-0446485-A2 | Peptide analogues with renininhibiting activity | MERCK PATENT GmbH (DE) | 1991-09-18 | — | — | EP | disclosed |
| EP-0418696-A2 | Derivatives of aminoacids | MERCK PATENT GmbH (DE) | 1991-03-27 | — | — | EP | disclosed |
| CN-1037155-A | Amino acid derivative | MERCK PATENT GMBH (DE) | 1989-11-15 | — | — | CN | disclosed |
| EP-0339483-A2 | Renin inhbiting amino-acid derivatives | MERCK PATENT GmbH (DE) | 1989-11-02 | — | — | EP | disclosed |
| EP-0337334-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1989-10-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376183-A1 | IP Receptor Agonist Heterocyclic Compounds | PTGIR, GPR68, GPR84 | TSHR 463/4885ALDH1A1 3232/4885CYP3A4 2298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.