Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.49 |
| ▸ | CDK1 | P06493 | 3/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.49 |
| ▸ | ABL1 | P00519 | 7/20 | 0.48 |
| ▸ | BCR | P11274 | 6/20 | 0.48 |
| ▸ | PRKCA | P17252 | 5/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 4/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 3/20 | 0.46 |
| ▸ | PRKACA | P17612 | 2/20 | 0.46 |
| ▸ | PRKACG | P22612 | 2/20 | 0.46 |
| ▸ | PRKACB | P22694 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3617870 | 0.85 | EIF2AK2 (0.59) | EIF2AK2BRD4CDK9CDK1CCNB1 | |
| SCHEMBL14123853 | 0.84 | CDK1 (0.64) | EIF2AK2BRD4CDK9CCNB2CDK1 | |
| SCHEMBL3937428 | 0.83 | HPGDS (0.45) | EIF2AK2BRD4CDK9ABL1BCR | |
| SCHEMBL3936435 | 0.80 | PIK3CD (0.42) | EIF2AK2BRD4CDK9ABL1BCR | |
| SCHEMBL3618907 | 0.80 | BRD4 (0.48) | EIF2AK2BRD4CDK9PRKCAPRKCD | |
| SCHEMBL13051126 | 0.80 | DYRK1B (0.60) | EIF2AK2CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL12723269 | 0.80 | CCNB2 (0.59) | EIF2AK2CDK9CCNB2CDK1CCNB1 | |
| SCHEMBL3620128 | 0.79 | CDK9 (0.64) | EIF2AK2BRD4CDK9CCNB2CDK1 | |
| SCHEMBL3615967 | 0.79 | BRD4 (0.47) | EIF2AK2BRD4CDK9CCNB2CDK1 | |
| SCHEMBL3931746 | 0.77 | PIK3CD (0.56) | PIK3CDPIK3CBPIK3CGHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100093776-A1 | Organic Compounds and Their Uses | NOVARTIS AG | 2010-04-15 | — | — | US | disclosed |
| US-20100093776-A1 | Organic Compounds and Their Uses | NOVARTIS AG | 2010-04-15 | — | — | US | disclosed |
| US-20100093776-A1 | Organic Compounds and Their Uses | NOVARTIS AG | 2010-04-15 | — | — | US | disclosed |
| WO-2008079918-A1 | INDOL-4-YL-PYRIMIDINYL-2-YL-AMINE DERIVATIVES AND USE THEREOF AS CYCLIN DEPENDANT KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093776-A1 | Organic Compounds and Their Uses | OAT, OTC, AOX1 | EIF2AK2 2174/4885BRD4 2447/4885CDK9 3238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.