Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 3/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5490434 | 0.78 | LMNA (0.43) | KMT2ALMNAMEN1THRBBLM | |
| SCHEMBL11875527 | 0.76 | CYP2C9 (0.41) | KMT2ALMNAMEN1THRBBLM | |
| SCHEMBL20206272 | 0.76 | NPC1 (0.42) | LMNATDP1ALDH1A1HPGDHTT | |
| SCHEMBL4790891 | 0.73 | MEN1 (0.49) | KMT2AMEN1TDP1CYP2C9CYP2C19 | |
| SCHEMBL964992 | 0.72 | LMNA (0.50) | KMT2ALMNAMEN1THRBBLM | |
| SCHEMBL3626947 | 0.71 | L3MBTL1 (0.43) | KMT2ALMNAMEN1TDP1ALDH1A1 | |
| SCHEMBL7122669 | 0.71 | MAPT (0.54) | KMT2ALMNAMEN1BLMTDP1 | |
| SCHEMBL7033768 | 0.71 | LMNA (0.55) | KMT2ALMNAMEN1THRBBLM | |
| SCHEMBL1325378 | 0.71 | LMNA (0.48) | KMT2ALMNAMEN1THRBBLM | |
| Hydrochloric Acid SCHEMBL7804693 | 0.71 | LMNA (0.48) | KMT2ALMNAMEN1THRBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6998489-B2 | Methods of making indazoles | ALCON, INC. (CH) | 2006-02-14 | — | — | US | claimed |
| EP-1392659-A4 | METHODS OF MAKING INDAZOLES | ALCON INC (CH) | 2004-10-20 | — | — | EP | claimed |
| US-20040142998-A1 | Methods of making indazoles | ALCON, INC. (CH) | 2004-07-22 | — | — | US | claimed |
| EP-1392659-A1 | METHODS OF MAKING INDAZOLES | Alcon, Inc. (CH) | 2004-03-03 | — | — | EP | claimed |
| WO-2002098862-A1 | METHODS OF MAKING INDAZOLES | ALCON, INC. (CH) | 2002-12-12 | — | — | WO | claimed |
| US-7799930-B2 | 1-alkyl-3-aminoindazoles | ALCON, INC. (CH) | 2010-09-21 | — | — | US | disclosed |
| US-20090149659-A1 | 1-ALKYL-3-AMINOINDAZOLES | ALCON, INC. (CH) | 2009-06-11 | — | — | US | disclosed |
| EP-1578729-A4 | 1-ALKYL-3-AMINOINDAZOLES | ALCON INC (CH) | 2007-08-29 | — | — | EP | disclosed |
| US-20060052613-A1 | 1-alkyl-3-aminoindazoles | ALCON, INC. (CH) | 2006-03-09 | — | — | US | disclosed |
| US-6998489-B2 | Methods of making indazoles | ALCON, INC. (CH) | 2006-02-14 | — | — | US | disclosed |
| EP-1578729-A1 | 1-ALKYL-3-AMINOINDAZOLES | Alcon, Inc. (CH) | 2005-09-28 | — | — | EP | disclosed |
| EP-1392659-A4 | METHODS OF MAKING INDAZOLES | ALCON INC (CH) | 2004-10-20 | — | — | EP | disclosed |
| WO-2004058725-A1 | 1-ALKYL-3-AMINOINDAZOLES | ALCON, INC. (CH) | 2004-07-15 | — | — | WO | disclosed |
| EP-1392659-A1 | METHODS OF MAKING INDAZOLES | Alcon, Inc. (CH) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002098862-A1 | METHODS OF MAKING INDAZOLES | ALCON, INC. (CH) | 2002-12-12 | — | — | WO | disclosed |
| US-5408021-A | Used in the fabrication of polymeric films for second order nonlinear optics | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1995-04-18 | — | — | US | disclosed |
| EP-0560909-B1 | POLYMERIC FILMS FOR SECOND ORDER NONLINEAR OPTICS | DU PONT (US) | 1994-11-23 | — | — | EP | disclosed |
| US-5294493-A | Multilayer | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0560909-A1 | POLYMERIC FILMS FOR SECOND ORDER NONLINEAR OPTICS. | DU PONT (US) | 1993-09-22 | — | — | EP | disclosed |
| WO-1992010781-A1 | POLYMERIC FILMS FOR SECOND ORDER NONLINEAR OPTICS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052613-A1 | 1-alkyl-3-aminoindazoles | NAT1, AADAC, CYP1B1 | KMT2A 2297/4885LMNA 1795/4885MEN1 1175/4885 |
| US-20040142998-A1 | Methods of making indazoles | NAT1, CYP3A5, ALDH3A1 | KMT2A 2228/4885LMNA 3826/4885MEN1 3316/4885 |
| US-20090149659-A1 | 1-ALKYL-3-AMINOINDAZOLES | NAT1, AADAC, CYP1B1 | KMT2A 2297/4885LMNA 1795/4885MEN1 1175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.