Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7804693 | 0.98 | LMNA (0.48) | LMNATDP1KMT2ATHRBMEN1 | |
| SCHEMBL28312506 | 0.83 | LMNA (0.46) | LMNATDP1KMT2ATHRBMEN1 | |
| SCHEMBL6880406 | 0.81 | TDP1 (0.41) | LMNATDP1KMT2ATHRBMEN1 | |
| SCHEMBL6286925 | 0.81 | TDP1 (0.41) | LMNATDP1KMT2ATHRBMEN1 | |
| SCHEMBL20628519 | 0.80 | ALDH1A1 (0.45) | LMNATDP1KMT2ATHRBMEN1 | |
| SCHEMBL1767594 | 0.79 | LMNA (0.44) | LMNATDP1KMT2ATHRBMEN1 | |
| SCHEMBL1767595 | 0.79 | LMNA (0.44) | LMNATDP1KMT2ATHRBMEN1 | |
| SCHEMBL7603406 | 0.79 | KMT2A (0.41) | LMNATDP1KMT2ATHRBMEN1 | |
| SCHEMBL2962223 | 0.78 | TDP1 (0.57) | LMNATDP1KMT2ATHRBMEN1 | |
| SCHEMBL874034 | 0.77 | TDP1 (0.55) | LMNATDP1KMT2ATHRBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4582903-A | Synthesis of unsaturated hydantoins with an inexpensive catalyst | STAUFFER CHEMICAL COMPANY (US) | 1986-04-15 | — | — | US | claimed |
| US-4345072-A | Process for the production of 5-arylidene hydantoins (B) | DEGUSSA AG (DE) | 1982-08-17 | — | — | US | claimed |
| US-9873692-B2 | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2018-01-23 | — | — | US | disclosed |
| US-20170334901-A1 | QUINOLINONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-11-23 | — | — | US | disclosed |
| US-9630960-B2 | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-04-25 | — | — | US | disclosed |
| US-20160376264-A1 | QUINOLINONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2016-12-29 | — | — | US | disclosed |
| US-9402840-B2 | Crystalline form of a quinolinone-carboxamide compound | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2016-08-02 | — | — | US | disclosed |
| US-9353106-B2 | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2016-05-31 | — | — | US | disclosed |
| US-20160095849-A1 | CRYSTALLINE FORM OF A QUINOLINONE-CARBOXAMIDE COMPOUND | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2016-04-07 | — | — | US | disclosed |
| US-20150291580-A1 | QUINOLINONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-10-15 | — | — | US | disclosed |
| US-9126994-B2 | Crystalline form of a quinolinone-carboxamide compound | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-09-08 | — | — | US | disclosed |
| US-4684735-A | Promotion of raney nickel hydrogenation catalyst | STAUFFER CHEMICAL COMPANY (US) | 1987-08-04 | — | — | US | disclosed |
| US-4650876-A | INCREMENTAL ADDITION TO PREVENT FOAMING, RANEY CATALYST | STAUFFER CHEMICAL COMPANY (US) | 1987-03-17 | — | — | US | disclosed |
| EP-0210683-A1 | Promotion of raney nickel catalyst | STAUFFER CHEMICAL COMPANY (US) | 1987-02-04 | — | — | EP | disclosed |
| US-4613691-A | Preparation of amino acids from unsaturated hydantoins | STAUFFER CHEMICAL COMPANY (US) | 1986-09-23 | — | — | US | disclosed |
| EP-0187322-A1 | Carbostyril compounds, compositions containing same and processes for preparing same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-07-16 | — | — | EP | disclosed |
| US-4582903-A | Synthesis of unsaturated hydantoins with an inexpensive catalyst | STAUFFER CHEMICAL COMPANY (US) | 1986-04-15 | — | — | US | disclosed |
| EP-0177072-A2 | Preparation of amino acids from unsaturated hydantoins | STAUFFER CHEMICAL COMPANY (US) | 1986-04-09 | — | — | EP | disclosed |
| EP-0082394-A2 | A process for the production of aminophthalides and amino benzoic acids | STERLING DRUG INC. (US) | 1983-06-29 | — | — | EP | disclosed |
| US-4345072-A | Process for the production of 5-arylidene hydantoins (B) | DEGUSSA AG (DE) | 1982-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160095849-A1 | CRYSTALLINE FORM OF A QUINOLINONE-CARBOXAMIDE COMPOUND | HTR5A, HTR4, HTR2C | LMNA 2512/4885TDP1 2252/4885KMT2A 1371/4885 |
| US-20160376264-A1 | QUINOLINONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | HTR4, HTR5A, HTR1A | LMNA 3482/4885TDP1 3148/4885KMT2A 1511/4885 |
| US-20150291580-A1 | QUINOLINONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | HTR4, HTR5A, HTR1A | LMNA 3482/4885TDP1 3148/4885KMT2A 1511/4885 |
| US-20170334901-A1 | QUINOLINONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | HTR4, HTR5A, HTR1A | LMNA 3482/4885TDP1 3148/4885KMT2A 1511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.