Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LIPE | Q05469 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | KDM4A | O75164 | 2/20 | 0.34 |
| ▸ | KDM5A | P29375 | 2/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3627153 | 0.95 | LMNA (0.39) | SMN1; SMN2LMNAFFAR1KMT2ARAB9A | |
| SCHEMBL3625775 | 0.91 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAFFAR1KMT2ARAB9A | |
| SCHEMBL3628846 | 0.83 | GUCY1B2 (0.41) | SMN1; SMN2LMNAFFAR1KMT2ARAB9A | |
| SCHEMBL4004433 | 0.83 | KEAP1 (0.45) | SMN1; SMN2LMNAKMT2ARAB9AATM | |
| SCHEMBL3628794 | 0.81 | MEN1 (0.45) | KMT2ARAB9AATMMEN1NPC1 | |
| SCHEMBL3996498 | 0.78 | KEAP1 (0.45) | KMT2AMEN1CRHBPMC4RCRHR2 | |
| SCHEMBL3998895 | 0.77 | KEAP1 (0.45) | SMN1; SMN2LMNAKMT2ARAB9AATM | |
| SCHEMBL3627484 | 0.77 | RAB9A (0.46) | SMN1; SMN2LMNAKMT2ARAB9AATM | |
| SCHEMBL3627139 | 0.77 | SYK (0.38) | SMN1; SMN2KMT2ARAB9AATMMEN1 | |
| SCHEMBL3996781 | 0.75 | GUCY1B2 (0.43) | SMN1; SMN2MAPTGUCY1B2GUCY1A2GUCY1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | claimed |
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |