Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 7/20 | 0.38 |
| ▸ | EIF4EBP1 | Q13541 | 3/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 2/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | ALKBH1 | Q13686 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3627409 | 0.90 | POLB (0.39) | MRGPRX4MEN1NPC1RAB9AKMT2A | |
| SCHEMBL3625402 | 0.90 | MEN1 (0.41) | PTGER1EIF4EBP1MEN1NPC1RAB9A | |
| SCHEMBL3996801 | 0.89 | KEAP1 (0.46) | PTGER1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL14952869 | 0.86 | MEN1 (0.47) | PTGER1MRGPRX4MEN1NPC1RAB9A | |
| SCHEMBL3625406 | 0.84 | PTGER1 (0.37) | PTGER1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL14952822 | 0.84 | POLB (0.40) | MEN1NPC1RAB9AKMT2AXDH | |
| SCHEMBL4001015 | 0.83 | KEAP1 (0.47) | PTGER1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL3627313 | 0.80 | RAB9A (0.47) | PTGER1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL3625775 | 0.79 | SMN1; SMN2 (0.46) | MRGPRX4MEN1NPC1RAB9AKMT2A | |
| SCHEMBL3998373 | 0.79 | KEAP1 (0.47) | MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | claimed |
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |