Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FER | P16591 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.39 |
| ▸ | PDE4A | P27815 | 3/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3630454 | 1.00 | KDM4E (0.41) | KDM4ESMN1; SMN2FERPDE4BPDE4D | |
| SCHEMBL3624947 | 0.85 | ACHE (0.46) | PDE4BPDE4DPDE4APDE4CROCK2 | |
| SCHEMBL3624945 | 0.85 | ACHE (0.46) | PDE4BPDE4DPDE4APDE4CROCK2 | |
| SCHEMBL3628370 | 0.84 | ROCK2 (0.53) | KDM4ESMN1; SMN2FERPDE4BPDE4D | |
| SCHEMBL3628372 | 0.84 | ROCK2 (0.53) | KDM4ESMN1; SMN2FERPDE4BPDE4D | |
| SCHEMBL3628132 | 0.84 | ROCK2 (0.43) | KDM4EFERPDE4BPDE4DPDE4A | |
| SCHEMBL3628130 | 0.84 | ROCK2 (0.43) | KDM4EFERPDE4BPDE4DPDE4A | |
| SCHEMBL1936927 | 0.82 | ROCK2 (0.35) | KDM4ESMN1; SMN2FERROCK2ROCK1 | |
| SCHEMBL1936926 | 0.82 | ROCK2 (0.35) | KDM4ESMN1; SMN2FERROCK2ROCK1 | |
| SCHEMBL3627799 | 0.81 | LMNA (0.49) | PDE4BPDE4DPDE4APDE4CROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010032875-A2 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2010-03-25 | — | — | WO | disclosed |