Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 5/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3626358 | 0.81 | MAPT (0.44) | POLBMAPTSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL3626353 | 0.81 | MAPT (0.44) | POLBMAPTSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL3616710 | 0.79 | POLB (0.42) | POLBMAPTSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL3627313 | 0.78 | RAB9A (0.47) | POLBMAPTSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL3620278 | 0.77 | RAB9A (0.50) | POLBMAPTSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL14952822 | 0.77 | POLB (0.40) | POLBMAPTSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL3627409 | 0.75 | POLB (0.39) | POLBMAPTSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL3627139 | 0.75 | SYK (0.38) | POLBMAPTSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL3031016 | 0.74 | GUCY1A1 (0.56) | — | |
| SCHEMBL3627484 | 0.74 | RAB9A (0.46) | POLBMAPTSMN1; SMN2KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | claimed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |