Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6371222 | 0.86 | TP53 (0.53) | KDM4EALDH1A1HSD17B10HPGDCFTR | |
| SCHEMBL16144436 | 0.84 | MMP2 (0.53) | KDM4EALDH1A1HSD17B10HPGDCFTR | |
| SCHEMBL6371982 | 0.83 | KDM4E (0.64) | KDM4EALDH1A1HSD17B10HPGDCFTR | |
| SCHEMBL27986063 | 0.82 | KDM4E (0.50) | KDM4EALDH1A1HSD17B10HPGDCFTR | |
| SCHEMBL23891117 | 0.81 | KDM4E (0.53) | KDM4EALDH1A1HSD17B10HPGDCFTR | |
| SCHEMBL14454233 | 0.81 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10HPGDCFTR | |
| SCHEMBL538290 | 0.80 | SMN1; SMN2 (0.55) | KDM4EALDH1A1HSD17B10HPGDCFTR | |
| SCHEMBL30598338 | 0.80 | SMN1; SMN2 (0.55) | KDM4EALDH1A1HSD17B10HPGDCFTR | |
| SCHEMBL2060980 | 0.80 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10HPGDCFTR | |
| SCHEMBL14606679 | 0.79 | ALDH1A1 (0.44) | KDM4EALDH1A1HSD17B10HPGDCFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838676-B2 | Beta-secretase modulators and methods of use | AMGEN INC. (US) | 2010-11-23 | — | — | US | disclosed |
| US-6884801-B1 | Imidazoline derivatives as alpha-1A adrenoceptor ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-26 | — | — | US | disclosed |