Tiludronic Acid

Tiludronic Acid

SCHEMBL3628467

O=P(O)(O)C(Sc1ccc(Cl)cc1)P(=O)(O)O.[NaH].[NaH]

nearest known ligand 0.96

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 4/20 0.96
MMP8 P22894 3/20 0.96
MMP14 P50281 2/20 0.96
MMP1 P03956 1/20 0.68
HSD17B10 Q99714 2/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
TSHR P16473 1/20 0.40
CA14 Q9ULX7 4/20 0.40
TRPA1 O75762 3/20 0.40
CA2 P00918 3/20 0.40
CA9 Q16790 3/20 0.40
MAPT P10636 2/20 0.40
NPSR1 Q6W5P4 2/20 0.40
CA12 O43570 2/20 0.40
CYP1A2 P05177 1/20 0.40
LMNA P02545 1/20 0.40
THRB P10828 1/20 0.40
PMP22 Q01453 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tiludronic Acid SCHEMBL8607914 0.98 MMP2 (0.92) MMP2MMP8MMP14MMP1HSD17B10
Tiludronic Acid SCHEMBL18988 0.98 MMP2 (1.00) MMP2MMP8MMP14MMP1HSD17B10
Tiludronic Acid SCHEMBL2067280 0.88 MMP2 (0.80) MMP2MMP8MMP14MMP1HSD17B10
SCHEMBL17954020 0.87 MMP2 (0.79) MMP2MMP8MMP14MMP1HSD17B10
Tiludronic Acid SCHEMBL7159094 0.85 MMP2 (0.77) MMP2MMP8MMP14MMP1HSD17B10
Tiludronic Acid SCHEMBL2326547 0.85 MMP2 (0.75) MMP2MMP8MMP14MMP1HSD17B10
Tiludronic Acid SCHEMBL2323298 0.85 MMP2 (0.75) MMP2MMP8MMP14MMP1HSD17B10
Tiludronic Acid SCHEMBL8607912 0.84 MMP2 (0.74) MMP2MMP8MMP14MMP1HSD17B10
Tiludronic Acid SCHEMBL41053 0.81 MMP1 (1.00) MMP2MMP8MMP14MMP1HSD17B10
SCHEMBL2150897 0.80 MMP2 (0.63) MMP2MMP8MMP14MMP1FDPS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106668067-A Antitumor combined medicine 暨南大学 2017-05-17 CN claimed
CN-206120771-U Medicine formulation 南京三迭纪医药科技有限公司 2017-04-26 CN disclosed
CN-206120770-U Medicine formulation 南京三迭纪医药科技有限公司 2017-04-26 CN disclosed
CN-106236715-A Pharmaceutical dosage forms and uses thereof 南京三迭纪医药科技有限公司 2016-12-21 CN disclosed
CN-103958513-B Hypoxanthine derivant hydrochloric acid salt ONO PHARMACEUTICAL CO.,LTD. (JP) 2015-12-23 CN disclosed
CN-103097353-B Immunomodulator and anti-inflammatory compound INCOZEN THERAPEUTICS PVT LTD 2015-03-04 CN disclosed
CN-103958513-A 6-Hydroxypurine derivative hydrochloride ONO PHARMACEUTICAL CO 2014-07-30 CN disclosed
CN-101801931-B Azabiphenylaminobenzoic acid derivatives as dhodh inhibitors ALMIRALL SA 2014-05-14 CN disclosed
CN-102846474-B Device and method for preparing vesica with inner and outer water phase gradient difference UNIV SHENYANG PHARMACEUTICAL 2014-04-09 CN disclosed
CN-103097353-A Novel immunomodulator and anti-inflammatory compounds INCOZEN THERAPEUTICS PVT LTD 2013-05-08 CN disclosed
CN-1062735-C Application of diphosphoric acid derivative in preparation of medicine for promoting bone repair SANOFI ELF (FR) 2001-03-07 CN disclosed
CN-1275123-A Prostaglandin agonists and their use to treat bone disorders PFIZER (US) 2000-11-29 CN disclosed
EP-0998934-A1 REMEDIES FOR INTRAMEDULLARY DISEASES TORAY INDUSTRIES, INC. (JP) 2000-05-10 EP disclosed
CN-1241176-A Prevention of loss and restoration of bone mass by certain prostaglandin agonists PFIZER (US) 2000-01-12 CN disclosed
US-5739381-A HEATING AQUEOUS SOLUTION OF DISODIUM TILUDRONATE HEMIHYDRATE, COOLING, FILTRATION OF FORMED MONOHYDRATE PRECIPITATE, DRYING SANOFI (FR) 1998-04-14 US disclosed
EP-0831789-A1 STABLE PHARMACEUTICAL COMPOSITIONS CONTAINING TILUDRONATE HYDRATES AND PROCESS FOR PRODUCING THE PHARMACEUTICAL COMPOSITIONS SANOFI (FR) 1998-04-01 EP disclosed
US-5656288-A SUBJECTING DISODIUM TILUDRONATE MONOHYDRATE TO AN EXCESS OF WATER TO OBTAIN DISODIUM TILUDRONATE TETRAHYDRATE; COMPOUNDING WITH SODIUM LAURYL SULFATE CARRIER SANOFI WINTHROP, INC. (US) 1997-08-12 US disclosed
WO-1996041618-A1 STABLE PHARMACEUTICAL COMPOSITIONS CONTAINING TILUDRONATE HYDRATES AND PROCESS FOR PRODUCING THE PHARMACEUTICAL COMPOSITIONS SANOFI (FR) 1996-12-27 WO disclosed
CN-1104091-A Application of diphosphoric acid derivative in preparation of medicine for promoting bone repair SANOFI ELF (FR) 1995-06-28 CN disclosed
US-5405994-A Antiarthritic agents SANOFI (FR) 1995-04-11 US disclosed