Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 11/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 11/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.41 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21724599 | 0.84 | FAAH (0.54) | HDAC11PLA2G2CMEN1FAAHMAPK1 | |
| SCHEMBL3628190 | 0.84 | KMT2A (0.46) | FOLH1HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL21724577 | 0.84 | FAAH (0.54) | HDAC11PLA2G2CMEN1FAAHMAPK1 | |
| SCHEMBL21724159 | 0.84 | FAAH (0.54) | HDAC11PLA2G2CMEN1FAAHMAPK1 | |
| SCHEMBL21724579 | 0.82 | FAAH (0.51) | HDAC11PLA2G2CMEN1FAAHMAPK1 | |
| SCHEMBL3625944 | 0.82 | CYP2D6 (0.44) | FOLH1HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL8399871 | 0.79 | PHF8 (0.41) | FOLH1ITGB3ITGA2B | |
| SCHEMBL15524955 | 0.78 | NOD1 (0.54) | FOLH1 | |
| SCHEMBL21724532 | 0.76 | HDAC3 (0.39) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL3626727 | 0.75 | PTGS1 (0.56) | HDAC3HDAC1HDAC2HDAC10HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522916-B2 | A1 adenosine receptor antagonists | WILSON CONSTANCE NEELY (US) | 2016-12-20 | — | — | US | disclosed |
| US-20140031375-A1 | A1 ADENOSINE RECEPTOR ANTAGONISTS | WILSON CONSTANCE NEELY (US) | 2014-01-30 | — | — | US | disclosed |
| EP-2222676-A2 | A1 ADENOSINE RECEPTOR ANTAGONISTS | Endacea, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009086077-A2 | A1 ADENOSINE RECEPTOR ANTAGONISTS | ENDACEA, INC. (US) | 2009-07-09 | — | — | WO | disclosed |
| US-20090068101-A9 | A1 Adenosine Receptor Antagonists | ENDACEA, INC. (US) | 2009-03-12 | — | — | US | disclosed |
| EP-1636229-A4 | A1 ADENOSINE RECEPTOR ANTOGONISTS | ENDACEA INC (US) | 2008-07-30 | — | — | EP | disclosed |
| US-20070282105-A1 | A1 ADENOSINE RECEPTOR ANTAGONISTS | ENDACEA, INC. (US) | 2007-12-06 | — | — | US | disclosed |
| US-20070274910-A1 | e.g. 3-[2-(2-Aminophenyl)ethyl]-8-benzyl-7-(2-methylamino)ethyl-1-propylxanthine; A1-adenosine receptor antagonist; antiallergen, antiinflammatory agent; AIDS and immune deficiency disorders, asthma; good water solubility | ENDACEA, INC. (US) | 2007-11-29 | — | — | US | disclosed |
| US-7247639-B2 | A1 adenosine receptor antagonists | ENDACEA, INC. (US) | 2007-07-24 | — | — | US | disclosed |
| EP-1636230-A2 | A1 ADENOSINE RECEPTOR ANTAGONISTS | Endacea, Inc. (US) | 2006-03-22 | — | — | EP | disclosed |
| EP-1636229-A2 | A1 ADENOSINE RECEPTOR ANTOGONISTS | Endacea, Inc. (US) | 2006-03-22 | — | — | EP | disclosed |
| US-20050187226-A1 | A1 adenosine receptor antagonists | ENDACEA, INC. | 2005-08-25 | — | — | US | disclosed |
| WO-2005009343-A2 | A1 ADENOSINE RECEPTOR ANTOGONISTS | ENDACEA, INC. (US) | 2005-02-03 | — | — | WO | disclosed |
| WO-2004110379-A2 | A1 ADENOSINE RECEPTOR ANTAGONISTS | ENDACEA, INC. (US) | 2004-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070282105-A1 | A1 ADENOSINE RECEPTOR ANTAGONISTS | ADORA1, ADORA3, ADORA2A | FOLH1 1642/4885HDAC3 4198/4885HDAC1 4369/4885 |
| US-20070274910-A1 | e.g. 3-[2-(2-Aminophenyl)ethyl]-8-benzyl-7-(2-methylamino)ethyl-1-propylxanthine; A1-adenosine receptor antagonist; antiallergen, antiinflammatory agent; AIDS and immune deficiency disorders, asthma; good water solubility | HRH3, HRH1, HRH2 | FOLH1 692/4885HDAC3 4325/4885HDAC1 4652/4885 |
| US-20140031375-A1 | A1 ADENOSINE RECEPTOR ANTAGONISTS | ADORA1, ADORA2A, ADORA3 | FOLH1 2064/4885HDAC3 4317/4885HDAC1 3378/4885 |
| US-20050187226-A1 | A1 adenosine receptor antagonists | ADORA1, ADORA2A, ADORA3 | FOLH1 996/4885HDAC3 3818/4885HDAC1 3836/4885 |
| US-20090068101-A9 | A1 Adenosine Receptor Antagonists | ADORA1, ADORA3, ADORA2A | FOLH1 282/4885HDAC3 2218/4885HDAC1 3481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.