Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 4/20 | 0.33 |
| ▸ | CCR3 | P51677 | 4/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | GCGR | P47871 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | PYGL | P06737 | 1/20 | 0.31 |
| ▸ | GCG | P01275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363811 | 0.93 | S1PR1 (0.36) | GPBAR1BRD4KDM4EALDH1A1HPGD | |
| SCHEMBL362795 | 0.89 | GPBAR1 (0.36) | GPBAR1BRD4ALDH1A1HPGDGCGR | |
| SCHEMBL362902 | 0.89 | GPBAR1 (0.45) | GPBAR1BRD4KDM4EALDH1A1HPGD | |
| SCHEMBL363289 | 0.86 | GPBAR1 (0.41) | GPBAR1BRD4KDM4EALDH1A1HPGD | |
| SCHEMBL365274 | 0.85 | GPBAR1 (0.46) | GPBAR1BRD4 | |
| SCHEMBL363112 | 0.85 | GPBAR1 (0.36) | GPBAR1BRD4ALDH1A1GCGRTP53 | |
| SCHEMBL362887 | 0.84 | GPBAR1 (0.39) | GPBAR1BRD4ALDH1A1HPGDTP53 | |
| SCHEMBL369578 | 0.84 | GPBAR1 (0.35) | GPBAR1BRD4KDM4EALDH1A1HPGD | |
| SCHEMBL369576 | 0.84 | GPBAR1 (0.35) | GPBAR1BRD4KDM4EALDH1A1HPGD | |
| SCHEMBL369579 | 0.84 | GPBAR1 (0.35) | GPBAR1BRD4KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | claimed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | claimed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |