Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.41 |
| ▸ | GCG | P01275 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 3/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.33 |
| ▸ | VEGFA | P15692 | 2/20 | 0.33 |
| ▸ | FLT1 | P17948 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.33 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.33 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.33 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.33 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL362887 | 0.93 | GPBAR1 (0.39) | GPBAR1GCGBRD4EGLN1ALDH1A1 | |
| SCHEMBL363976 | 0.90 | GPBAR1 (0.41) | GPBAR1GCGBRD4EGLN1VEGFA | |
| SCHEMBL363178 | 0.89 | GPBAR1 (0.51) | GPBAR1BRD4MEN1CYP1A2KMT2A | |
| SCHEMBL362795 | 0.88 | GPBAR1 (0.36) | GPBAR1GCGBRD4GCGRALDH1A1 | |
| SCHEMBL362350 | 0.86 | GPBAR1 (0.48) | GPBAR1BRD4CYP2D6SLC6A9SMN1; SMN2 | |
| SCHEMBL363066 | 0.86 | GPBAR1 (0.35) | GPBAR1GCGBRD4GCGRALDH1A1 | |
| SCHEMBL365274 | 0.86 | GPBAR1 (0.46) | GPBAR1BRD4MEN1CYP1A2KMT2A | |
| SCHEMBL363112 | 0.85 | GPBAR1 (0.36) | GPBAR1GCGBRD4GCGRALDH1A1 | |
| SCHEMBL1389596 | 0.84 | GPBAR1 (0.41) | GPBAR1GCGGCGREGLN1VEGFA | |
| SCHEMBL1389593 | 0.84 | GPBAR1 (0.41) | GPBAR1GCGGCGREGLN1VEGFA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | claimed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | claimed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |