Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | GCG | P01275 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PNP | P00491 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363289 | 0.93 | GPBAR1 (0.41) | GPBAR1MEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL363619 | 0.91 | GPBAR1 (0.39) | GPBAR1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL363178 | 0.87 | GPBAR1 (0.51) | GPBAR1MEN1KMT2ACYP1A2POLB | |
| SCHEMBL362795 | 0.86 | GPBAR1 (0.36) | GPBAR1MEN1KMT2AALDH1A1GCG | |
| SCHEMBL1389689 | 0.84 | GPBAR1 (0.39) | GPBAR1MEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL1389691 | 0.84 | GPBAR1 (0.39) | GPBAR1MEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL363066 | 0.84 | GPBAR1 (0.35) | GPBAR1ALDH1A1GCGTP53HPGD | |
| SCHEMBL365274 | 0.84 | GPBAR1 (0.46) | GPBAR1MEN1KMT2ACYP1A2POLB | |
| SCHEMBL365164 | 0.84 | GPBAR1 (0.37) | GPBAR1MEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL363112 | 0.83 | GPBAR1 (0.36) | GPBAR1ALDH1A1GCGTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | claimed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | claimed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |