Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.35 |
| ▸ | GCGR | P47871 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 3/20 | 0.33 |
| ▸ | GCG | P01275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363587 | 0.93 | GCGR (0.38) | GPBAR1EPHX2GCGRBRD4TP53 | |
| SCHEMBL362795 | 0.90 | GPBAR1 (0.36) | GPBAR1EPHX2GCGRBRD4POLB | |
| SCHEMBL363032 | 0.90 | GPBAR1 (0.45) | GPBAR1EPHX2BRD4POLB | |
| SCHEMBL363289 | 0.85 | GPBAR1 (0.41) | GPBAR1EPHX2GCGRBRD4ALDH1A1 | |
| SCHEMBL363066 | 0.85 | GPBAR1 (0.35) | GPBAR1EPHX2GCGRBRD4TP53 | |
| SCHEMBL365274 | 0.85 | GPBAR1 (0.46) | GPBAR1BRD4POLB | |
| SCHEMBL369287 | 0.84 | GPBAR1 (0.36) | GPBAR1EPHX2GCGRBRD4TP53 | |
| SCHEMBL369285 | 0.84 | GPBAR1 (0.36) | GPBAR1EPHX2GCGRBRD4TP53 | |
| SCHEMBL369286 | 0.84 | GPBAR1 (0.36) | GPBAR1EPHX2GCGRBRD4TP53 | |
| SCHEMBL362887 | 0.83 | GPBAR1 (0.39) | GPBAR1BRD4TP53POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | claimed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | claimed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |